Agpat5 MGI Mouse Gene Detail - MGI:1196345 - 1-acylglycerol-3-phosphate O-acyltransferase 5

Symbol

Agpat5
Name

1-acylglycerol-3-phosphate O-acyltransferase 5
Synonyms

1110013A05Rik, D8Ertd319e

Feature Type

protein coding gene
IDs

MGI:1196345
NCBI Gene: 52123
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:18896295-18934429 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 10.30 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

1223 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196345	protein coding gene	Chr8:18896293-18941377 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033405	protein coding gene	Chr8:16319946-16365777 (+)
A/J	MGP_AJ_G0033386	protein coding gene	Chr8:15762961-15800112 (+)
AKR/J	MGP_AKRJ_G0033316	protein coding gene	Chr8:16213973-16263135 (+)
BALB/cJ	MGP_BALBcJ_G0033386	protein coding gene	Chr8:15871200-15916643 (+)
C3H/HeJ	MGP_C3HHeJ_G0033099	protein coding gene	Chr8:16409321-16455605 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033898	protein coding gene	Chr8:16852718-16899191 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030864	protein coding gene	Chr8:15065040-15107575 (+)
CAST/EiJ	MGP_CASTEiJ_G0032421	protein coding gene	Chr8:16262818-16309622 (+)
CBA/J	MGP_CBAJ_G0033072	protein coding gene	Chr8:17579217-17617831 (+)
DBA/2J	MGP_DBA2J_G0033226	protein coding gene	Chr8:15722860-15768219 (+)
FVB/NJ	MGP_FVBNJ_G0033174	protein coding gene	Chr8:15717290-15763643 (+)
LP/J	MGP_LPJ_G0033319	protein coding gene	Chr8:16348894-16395132 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033211	protein coding gene	Chr8:17738876-17785163 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033915	protein coding gene	Chr8:16237732-16282813 (+)
PWK/PhJ	MGP_PWKPhJ_G0032134	protein coding gene	Chr8:15732310-15778357 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031975	protein coding gene	Chr8:16159170-16203664 (+)
WSB/EiJ	MGP_WSBEiJ_G0032537	protein coding gene	Chr8:16321501-16367686 (+)

Human Ortholog

AGPAT5, 1-acylglycerol-3-phosphate O-acyltransferase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGPAT5, 1-acylglycerol-3-phosphate O-acyltransferase 5
Synonyms

1AGPAT5, LPAATE, LPLAT5
Links

HGNC:20886

NCBI Gene ID: 55326

neXtProt AC: NX_Q9NUQ2

UniProt: Q9NUQ2
Chr Location

8p23.1; chr8:6708642-6761503 (+) GRCh38

MGI Vertebrate Homology

Agpat5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGPAT5
Gene Tree

Agpat5

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

4
Gene trapped

16
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display moderate fatty changes in the liver.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

969
Tissues

130
cDNA Data

15
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AGPAT5

Xenbase agpat5

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All Sequences

49
RefSeq

2
UniProt

3
CCDS

CCDS22126.1

Ensembl

ENSMUSG00000031467 (Evidence)
NCBI Gene

52123

			Length	Strain/Species	Flank
genomic	52123	NCBI Gene Model \| MGI Sequence Detail	38135	C57BL/6J	± kb
transcript	NM_026792	RefSeq \| MGI Sequence Detail	3829	ZRU/MplStud
polypeptide	Q9D1E8	UniProt \| EBI \| MGI Sequence Detail	365	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003838 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

(term hierarchy)
EC

2.3.1.51
InterPro Domains

IPR032098 Acyltransferase, C-terminal domain

IPR002123 Phospholipid/glycerol acyltransferase

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 6

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MGI:1915880

Summaries

All 44

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Agpat5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76523	Chr8:18896267-18896344 (+)	11 bp
Tssr76524	Chr8:18896484-18896505 (+)	200 bp
Tssr76525	Chr8:18896507-18896528 (+)	223 bp
Tssr76526	Chr8:18896540-18896560 (+)	255 bp
Tssr76527	Chr8:18896596-18896609 (+)	308 bp
Tssr76528	Chr8:18932242-18932261 (+)	35,957 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24