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Iqsec1 Gene Detail
Summary
  • Symbol
    Iqsec1
  • Name
    IQ motif and Sec7 domain 1
  • Synonyms
    BRAG2, cI-43, D6Ertd349e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196356
    NCBI Gene: 232227
  • Alliance
    gene page
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:90636578-90965766 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 40.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6338 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196356
 protein coding gene Chr6:90633070-90965766 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031041
 protein coding gene Chr6:92205639-92368312 (-)
A/J MGP_AJ_G0031009
 protein coding gene Chr6:88692028-88849474 (-)
AKR/J MGP_AKRJ_G0030941
 protein coding gene Chr6:91165294-91319377 (-)
BALB/cJ MGP_BALBcJ_G0031021
 protein coding gene Chr6:88642753-88797148 (-)
C3H/HeJ MGP_C3HHeJ_G0030687
 protein coding gene Chr6:93119728-93276389 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031480
 protein coding gene Chr6:94626935-94784678 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028648
 protein coding gene Chr6:86682616-86836672 (-)
CAST/EiJ MGP_CASTEiJ_G0030128
 protein coding gene Chr6:91275284-91432083 (-)
CBA/J MGP_CBAJ_G0030707
 protein coding gene Chr6:98155156-98313725 (-)
DBA/2J MGP_DBA2J_G0030860
 protein coding gene Chr6:87883571-88043146 (-)
FVB/NJ MGP_FVBNJ_G0030814
 protein coding gene Chr6:87089072-87244550 (-)
LP/J MGP_LPJ_G0030940
 protein coding gene Chr6:92173488-92331871 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030848
 protein coding gene Chr6:102232962-102397547 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031507
 protein coding gene Chr6:91006520-91164546 (-)
PWK/PhJ MGP_PWKPhJ_G0029844
 protein coding gene Chr6:86828700-86984185 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029673
 protein coding gene Chr6:89910516-90069178 (-)
WSB/EiJ MGP_WSBEiJ_G0030212
 protein coding gene Chr6:91469940-91628831 (-)



Homology
more
  • Human Ortholog
    IQSEC1, IQ motif and Sec7 domain ArfGEF 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IQSEC1, IQ motif and Sec7 domain ArfGEF 1
  • Synonyms
    ARF-GEP100, ARFGEP100, BRAG2, GEP100, IDDSSBA
  • Links
    NCBI Gene ID: 9922
    neXtProt AC: NX_Q6DN90
    UniProt: Q6DN90

  • Chr Location
    3p25.2-p25.1; chr3:12897043-13283281 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human IQSEC1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neurons fail to exhibit mGluR- and NMDAR-mediated long term depression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    17
  • cDNA Data
    12
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 232227 NCBI Gene Model | MGI Sequence Detail 329189 C57BL/6J ±  kb
transcript NM_001408946 RefSeq | MGI Sequence Detail 6696 ZRU/MplStud  
polypeptide Q8R0S2 UniProt | EBI | MGI Sequence Detail 961 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009098 IQ motif and SEC7 domain-containing protein 1
    (term hierarchy)
  • InterPro Domains
    IPR033742 IQ motif and SEC7 domain-containing protein, PH domain
    IPR011993 PH-like domain superfamily
    IPR023394 Sec7, C-terminal domain superfamily
    IPR000904 Sec7 domain
    IPR035999 Sec7 domain superfamily
  • GlyGen
    Q8R0S2 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:1930797, MGI:2446231
References
more
  • Summaries
    All 48
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory