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Ildr2 Gene Detail
Summary
  • Symbol
    Ildr2
  • Name
    immunoglobulin-like domain containing receptor 2
  • Synonyms
    2810478N18Rik, 3110063L10Rik, D1Ertd471e, Dbsm1, ENSMUSG00000040612, OTTMUSG00000021748
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196370
    NCBI Gene: 100039795
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:166081708-166144392 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 73.61 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1758 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196370
 protein coding gene Chr1:166081630-166144405 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016703
 protein coding gene Chr1:171773670-171840279 (+)
A/J MGP_AJ_G0016684
 protein coding gene Chr1:164790507-164853049 (+)
AKR/J MGP_AKRJ_G0016650
 protein coding gene Chr1:169757663-169820988 (+)
BALB/cJ MGP_BALBcJ_G0016645
 protein coding gene Chr1:165259940-165322259 (+)
C3H/HeJ MGP_C3HHeJ_G0016469
 protein coding gene Chr1:169975535-170036847 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017106
 protein coding gene Chr1:177529810-177592939 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014815
 protein coding gene Chr1:156649012-156711142 (+)
CAST/EiJ MGP_CASTEiJ_G0016049
 protein coding gene Chr1:169568753-169634650 (+)
CBA/J MGP_CBAJ_G0016444
 protein coding gene Chr1:183853200-183917272 (+)
DBA/2J MGP_DBA2J_G0016550
 protein coding gene Chr1:163650271-163716589 (+)
FVB/NJ MGP_FVBNJ_G0016548
 protein coding gene Chr1:162084660-162147554 (+)
LP/J MGP_LPJ_G0016621
 protein coding gene Chr1:172859893-172923593 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016573
 protein coding gene Chr1:191290281-191353610 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017142
 protein coding gene Chr1:169620769-169683758 (+)
PWK/PhJ MGP_PWKPhJ_G0015835
 protein coding gene Chr1:162861602-162951195 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015622
 protein coding gene Chr1:168459011-168550463 (+)
WSB/EiJ MGP_WSBEiJ_G0016111
 protein coding gene Chr1:169756294-169816292 (+)



Homology
more
  • Human Ortholog
    ILDR2, immunoglobulin like domain containing receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ILDR2, immunoglobulin like domain containing receptor 2
  • Synonyms
    C1orf32, dJ782G3.1
  • Links
    NCBI Gene ID: 387597
    neXtProt AC: NX_Q71H61
    UniProt: Q71H61

  • Chr Location
    1q24.1; chr1:166895711-166975540 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced stop mutation at threonine-87 display a reduced pancreatic beta-cell replication rate, decreased beta-cell mass, reduced insulin/glucose ratio in blood, impaired glucose tolerance, and persistent mild hypoinsulinemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    49
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040612 Ensembl Gene Model | MGI Sequence Detail 62685 C57BL/6J ±  kb
    transcript ENSMUST00000111416 Ensembl | MGI Sequence Detail 8251 Not Applicable  
    polypeptide ENSMUSP00000107047 Ensembl | MGI Sequence Detail 661 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 49
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1920058, MGI:1920459, MGI:2138362, MGI:3641863, MGI:3814221
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:54765 Bergstrom DE, et al., Genetic and physical mapping of the Dreher locus on mouse Chromosome 1. Genomics. 1999;59:291-9
    • Latest
      J:347596 Higashi AY, et al., Bicellular Localization of Tricellular Junctional Protein Angulin-3/ILDR2 Allows Detection of Podocyte Injury. Am J Pathol. 2024 May;194(5):673-683
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory