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Hltf Gene Detail
Summary
  • Symbol
    Hltf
  • Name
    helicase-like transcription factor
  • Synonyms
    P113, Smarca3, Snf2l3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196437
    NCBI Gene: 20585
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:20111975-20172654 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 6.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2202 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196437
 protein coding gene Chr3:20111959-20172655 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027099
 protein coding gene Chr3:17263057-17346136 (+)
A/J MGP_AJ_G0027059
 protein coding gene Chr3:17187035-17251526 (+)
AKR/J MGP_AKRJ_G0027028
 protein coding gene Chr3:17360152-17435532 (+)
BALB/cJ MGP_BALBcJ_G0027071
 protein coding gene Chr3:16938817-17000763 (+)
C3H/HeJ MGP_C3HHeJ_G0026812
 protein coding gene Chr3:17377899-17455108 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027516
 protein coding gene Chr3:18370137-18444469 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024878
 protein coding gene Chr3:15241254-15300117 (+)
CAST/EiJ MGP_CASTEiJ_G0026267
 protein coding gene Chr3:17282490-17347170 (+)
CBA/J MGP_CBAJ_G0026790
 protein coding gene Chr3:18767309-18848370 (+)
DBA/2J MGP_DBA2J_G0026924
 protein coding gene Chr3:16804731-16865758 (+)
FVB/NJ MGP_FVBNJ_G0026892
 protein coding gene Chr3:16461109-16526196 (+)
LP/J MGP_LPJ_G0027036
 protein coding gene Chr3:17911931-17983994 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026913
 protein coding gene Chr3:20829579-20904467 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027576
 protein coding gene Chr3:17144044-17208021 (+)
PWK/PhJ MGP_PWKPhJ_G0026000
 protein coding gene Chr3:16506911-16566110 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025809
 protein coding gene Chr3:16943228-17004448 (+)
WSB/EiJ MGP_WSBEiJ_G0026340
 protein coding gene Chr3:17148185-17213911 (+)



Homology
more
  • Human Ortholog
    HLTF, helicase like transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLTF, helicase like transcription factor
  • Synonyms
    HIP116, HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3, ZBU1
  • Links
    NCBI Gene ID: 6596
    neXtProt AC: NX_Q14527
    UniProt: Q14527

  • Chr Location
    3q24; chr3:149030063-149086554 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, spongiform encephalopathy with increased brain apoptosis, and hypoglycemia. Mice homozygous for a different knock-out allele fail to show fluoxetine-induced neurogenesis and behavioral responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    181
  • cDNA Data
    20
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002428 Ensembl Gene Model | MGI Sequence Detail 60680 C57BL/6J ±  kb
    transcript ENSMUST00000002502 Ensembl | MGI Sequence Detail 4955 Not Applicable  
    polypeptide ENSMUSP00000002502 Ensembl | MGI Sequence Detail 1003 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 20
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2139614, MGI:3039609
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:314095 Osborn M, et al., The submembranous location of p11 and its interaction with the p36 substrate of pp60 src kinase in situ. Exp Cell Res. 1988 Mar;175(1):81-96
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory