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Slc4a1ap Gene Detail
Summary
  • Symbol
    Slc4a1ap
  • Name
    solute carrier family 4 (anion exchanger), member 1, adaptor protein
  • Synonyms
    kanadaptin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196608
    NCBI Gene: 20534
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31684125-31711386 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    759 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196608
 protein coding gene Chr5:31684125-31714276 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029429
 protein coding gene Chr5:29549304-29582307 (+)
A/J MGP_AJ_G0029395
 protein coding gene Chr5:28600310-28630507 (+)
AKR/J MGP_AKRJ_G0029345
 protein coding gene Chr5:29751201-29781299 (+)
BALB/cJ MGP_BALBcJ_G0029406
 protein coding gene Chr5:29130724-29161168 (+)
C3H/HeJ MGP_C3HHeJ_G0029127
 protein coding gene Chr5:29770766-29802630 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029859
 protein coding gene Chr5:31376596-31406198 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027097
 protein coding gene Chr5:26204696-26233764 (+)
CAST/EiJ MGP_CASTEiJ_G0028537
 protein coding gene Chr5:28807001-28838939 (+)
CBA/J MGP_CBAJ_G0029095
 protein coding gene Chr5:32007125-32040288 (+)
DBA/2J MGP_DBA2J_G0029244
 protein coding gene Chr5:28760986-28791120 (+)
FVB/NJ MGP_FVBNJ_G0029202
 protein coding gene Chr5:28181083-28210844 (+)
LP/J MGP_LPJ_G0029329
 protein coding gene Chr5:30001184-30033011 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029231
 protein coding gene Chr5:32834470-32868050 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029893
 protein coding gene Chr5:29249079-29278858 (+)
PWK/PhJ MGP_PWKPhJ_G0028262
 protein coding gene Chr5:27915526-27949446 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028093
 protein coding gene Chr5:28712059-28743972 (+)
WSB/EiJ MGP_WSBEiJ_G0028618
 protein coding gene Chr5:29318149-29350243 (+)



Homology
more
  • Human Ortholog
    SLC4A1AP, solute carrier family 4 member 1 adaptor protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC4A1AP, solute carrier family 4 member 1 adaptor protein
  • Synonyms
    HLC3
  • Links
    NCBI Gene ID: 22950
    neXtProt AC: NX_Q9BWU0
    UniProt: Q9BWU0

  • Chr Location
    2p23.3; chr2:27663426-27695366 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    56
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20534 NCBI Gene Model | MGI Sequence Detail 27262 C57BL/6J ±  kb
    transcript NM_001347328 RefSeq | MGI Sequence Detail 2512 C57BL/6  
    polypeptide NP_001334257 RefSeq | MGI Sequence Detail 744 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR050923 Cellular Process Regulator and RNA Processing Protein
      IPR014720 Double-stranded RNA-binding domain
      IPR000253 Forkhead-associated (FHA) domain
      IPR008984 SMAD/FHA domain superfamily
    • GlyGen
      E9PX68 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 2
    References
    more
    • Summaries
      All 52
      Diseases 1
      Gene Ontology 3
      Phenotypes 31
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory