Ninj1 MGI Mouse Gene Detail - MGI:1196617

Symbol

Ninj1
Name

ninjurin 1

Feature Type

protein coding gene
IDs

MGI:1196617
NCBI Gene: 18081
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr13:49341005-49349727 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 25.14 cM
Mapping Data

3 experiments

SNPs within 2kb

263 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196617	protein coding gene	Chr13:49340961-49349727 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020530	protein coding gene	Chr13:48152306-48161065 (+)
A/J	MGP_AJ_G0020484	protein coding gene	Chr13:46440117-46448876 (+)
AKR/J	MGP_AKRJ_G0020461	protein coding gene	Chr13:47753522-47762288 (+)
BALB/cJ	MGP_BALBcJ_G0020480	protein coding gene	Chr13:46654346-46663105 (+)
C3H/HeJ	MGP_C3HHeJ_G0020279	protein coding gene	Chr13:47574587-47583345 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020913	protein coding gene	Chr13:49604853-49613612 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018498	protein coding gene	Chr13:44419394-44428607 (+)
CAST/EiJ	MGP_CASTEiJ_G0019794	protein coding gene	Chr13:47579894-47594141 (+)
CBA/J	MGP_CBAJ_G0020240	protein coding gene	Chr13:51654078-51662837 (+)
DBA/2J	MGP_DBA2J_G0020362	protein coding gene	Chr13:45965262-45974021 (+)
FVB/NJ	MGP_FVBNJ_G0020341	protein coding gene	Chr13:45483641-45492386 (+)
LP/J	MGP_LPJ_G0020437	protein coding gene	Chr13:48375272-48384031 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020370	protein coding gene	Chr13:51367339-51376098 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020956	protein coding gene	Chr13:47452949-47461709 (+)
PWK/PhJ	MGP_PWKPhJ_G0019550	protein coding gene	Chr13:46145316-46154047 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019378	protein coding gene	Chr13:46155035-46164553 (+)
WSB/EiJ	MGP_WSBEiJ_G0019856	protein coding gene	Chr13:47764222-47773111 (+)

Human Ortholog

NINJ1, ninjurin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NINJ1, ninjurin 1
Synonyms

hNINJ1, NIN1, NINJURIN
Links

HGNC:7824

NCBI Gene ID: 4814

neXtProt AC: NX_Q92982

UniProt: Q92982
Chr Location

9q22.31; chr9:93121496-93134251 (-) GRCh38

MGI Vertebrate Homology

Ninj1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NINJ1
Gene Tree

Ninj1

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Phenotype Summary

12 phenotypes from 3 alleles in 3 genetic backgrounds
2 images
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

5
Genomic Mutations

1 involving Ninj1
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available

Homozygotes for a null allele die prematurely exhibiting hydroencephaly and abnormal cellular replicative senescence. Homozygotes for another null allele show resistance to EAE due to reduced leukocyte recruitment into lesion sites, and may display stunted growth, hydroencephaly, and ataxia.

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All GO Annotations

50
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1155
Tissues

51
cDNA Data

81
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ninj1

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All Sequences

57
RefSeq

2
UniProt

5
CCDS

CCDS26497.1

Ensembl

ENSMUSG00000037966 (Evidence)
NCBI Gene

18081

			Length	Strain/Species	Flank
genomic	18081	NCBI Gene Model \| MGI Sequence Detail	8723	C57BL/6J	± kb
transcript	NM_013610	RefSeq \| MGI Sequence Detail	1150	C57BL/6
polypeptide	O70131	UniProt \| EBI \| MGI Sequence Detail	152	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011213 ninjurin-1

(term hierarchy)
InterPro Domains

IPR007007 Ninjurin
GlyGen

O70131 1 site

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All nucleic 82

Genomic 1

cDNA 81

Microarray probesets 4

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MGI:2145366

Summaries

All 67

Developmental Gene Expression 4

Gene Ontology 22

Phenotypes 23
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:352410 Ramos S, et al., NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis. EMBO J. 2024 Apr;43(7):1164-1186

TSS for Ninj1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119678	Chr13:49340961-49341015 (+)	-17 bp
Tssr119679	Chr13:49341632-49341643 (+)	633 bp
Tssr119680	Chr13:49341678-49341692 (+)	680 bp
Tssr119681	Chr13:49341721-49341737 (+)	724 bp
Tssr119682	Chr13:49341984-49342034 (+)	1,004 bp
Tssr119683	Chr13:49343805-49343807 (+)	2,801 bp
Tssr119684	Chr13:49343828-49343834 (+)	2,826 bp
Tssr119685	Chr13:49344429-49344435 (+)	3,427 bp
Tssr119686	Chr13:49344547-49344560 (+)	3,549 bp
Tssr119687	Chr13:49347201-49347236 (+)	6,214 bp
Tssr119688	Chr13:49347337-49347393 (+)	6,360 bp
Tssr119689	Chr13:49349160-49349175 (+)	8,163 bp
Tssr119690	Chr13:49349186-49349214 (+)	8,195 bp
Tssr119691	Chr13:49349404-49349429 (+)	8,412 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24