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Birc2 Gene Detail
Summary
  • Symbol
    Birc2
  • Name
    baculoviral IAP repeat-containing 2
  • Synonyms
    Api1, C330006D17Rik, cIAP-1, cIAP1, HIAP1, IAP1, mcIAP1, MIAP1, MIHB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197009
    NCBI Gene: 11797
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7818228-7837065 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    539 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197009
 protein coding gene Chr9:7818227-7837123 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034329
 protein coding gene Chr9:4673688-4693299 (-)
A/J MGP_AJ_G0034307
 protein coding gene Chr9:4790930-4816031 (-)
AKR/J MGP_AKRJ_G0034235
 protein coding gene Chr9:4658227-4679100 (-)
BALB/cJ MGP_BALBcJ_G0034301
 protein coding gene Chr9:4527748-4546465 (-)
C3H/HeJ MGP_C3HHeJ_G0034012
 protein coding gene Chr9:4840801-4860332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034823
 protein coding gene Chr9:4849137-4869045 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031761
 protein coding gene Chr9:4025778-4042530 (-)
CAST/EiJ MGP_CASTEiJ_G0033340
 protein coding gene Chr9:4866466-4884473 (-)
CBA/J MGP_CBAJ_G0033985
 protein coding gene Chr9:4978148-5002382 (-)
DBA/2J MGP_DBA2J_G0034142
 protein coding gene Chr9:4658375-4679531 (-)
FVB/NJ MGP_FVBNJ_G0034087
 protein coding gene Chr9:4438277-4457222 (-)
LP/J MGP_LPJ_G0034228
 protein coding gene Chr9:4733399-4753206 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034131
 protein coding gene Chr9:5721493-5742167 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034842
 protein coding gene Chr9:4648148-4672211 (-)
PWK/PhJ MGP_PWKPhJ_G0033043
 protein coding gene Chr9:4781690-4801983 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032881
 protein coding gene Chr9:4896804-4917384 (-)
WSB/EiJ MGP_WSBEiJ_G0033455
 protein coding gene Chr9:4668493-4687692 (-)



Homology
more
  • Human Ortholog
    BIRC2, baculoviral IAP repeat containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BIRC2, baculoviral IAP repeat containing 2
  • Synonyms
    API1, c-IAP1, cIAP1, Hiap-2, HIAP2, MIHB, RNF48
  • Links
    NCBI Gene ID: 329
    neXtProt AC: NX_Q13490
    UniProt: Q13490

  • Chr Location
    11q22.2; chr11:102347211-102378670 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BIRC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice showed a modest reduction in the number of lymphocytes. Mice homozygous for a knock-in allele exhibit increased T cell poliferation and IFNG secretion in response to anti-CD3 stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    37
  • cDNA Data
    12
  • Literature Summary
    16
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057367 Ensembl Gene Model | MGI Sequence Detail 18838 C57BL/6J ±  kb
transcript ENSMUST00000190341 Ensembl | MGI Sequence Detail 3331 Not Applicable  
polypeptide ENSMUSP00000140049 Ensembl | MGI Sequence Detail 612 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 12
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1924866, MGI:2143294
References
more
  • Summaries
    All 107
    Developmental Gene Expression 16
    Gene Ontology 15
    Phenotypes 33
  • Earliest
    J:30406 Rothe M, et al., The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 1995 Dec 29;83(7):1243-52
  • Latest
    J:342656 Schorn F, et al., cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J. 2023 Nov 15;42(22):e113614
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory