Irx1 MGI Mouse Gene Detail - MGI:1197515

Symbol

Irx1
Name

Iroquois homeobox 1

Feature Type

protein coding gene
IDs

MGI:1197515
NCBI Gene: 16371
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:72106351-72111842 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 38.43 cM
Mapping Data

4 experiments

SNPs within 2kb

146 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1197515	protein coding gene	Chr13:72106040-72111842 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020739	protein coding gene	Chr13:72306689-72312498 (-)
A/J	MGP_AJ_G0020695	protein coding gene	Chr13:69759994-69765791 (-)
AKR/J	MGP_AKRJ_G0020670	protein coding gene	Chr13:71975798-71982208 (-)
BALB/cJ	MGP_BALBcJ_G0020692	protein coding gene	Chr13:70272281-70278067 (-)
C3H/HeJ	MGP_C3HHeJ_G0020487	protein coding gene	Chr13:71682787-71689200 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021129	protein coding gene	Chr13:74773038-74779957 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018697	protein coding gene	Chr13:66607155-66612976 (-)
CAST/EiJ	MGP_CASTEiJ_G0020004	protein coding gene	Chr13:70718410-70724071 (-)
CBA/J	MGP_CBAJ_G0020445	protein coding gene	Chr13:77631492-77644914 (-)
DBA/2J	MGP_DBA2J_G0020571	protein coding gene	Chr13:69606828-69612621 (-)
FVB/NJ	MGP_FVBNJ_G0020551	protein coding gene	Chr13:68616577-68623146 (-)
LP/J	MGP_LPJ_G0020643	protein coding gene	Chr13:72582846-72589543 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020579	protein coding gene	Chr13:76037864-76045230 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021168	protein coding gene	Chr13:71276431-71282441 (-)
PWK/PhJ	MGP_PWKPhJ_G0019758	protein coding gene	Chr13:68320508-68326766 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019581	protein coding gene	Chr13:67745765-67751600 (-)
WSB/EiJ	MGP_WSBEiJ_G0020061	protein coding gene	Chr13:71817282-71824312 (-)

Human Ortholog

IRX1, iroquois homeobox 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRX1, iroquois homeobox 1
Synonyms

IRX-5, IRXA1
Links

HGNC:14358

NCBI Gene ID: 79192

neXtProt AC: NX_P78414

UniProt: P78414
Chr Location

5p15.33; chr5:3595832-3601403 (+) GRCh38

MGI Vertebrate Homology

Irx1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IRX1
Gene Tree

Irx1

Diseases

1 with human IRX1 associations

				Human Disease	Mouse Models
				congenital heart disease IDs congenital heart disease DOID:1682 ICD10CM:Q24.9 ICD9CM:746.9 MESH:D006330 NCI:C34666 UMLS_CUI:C0018798

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

28 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

2
Genomic Mutations

1 involving Irx1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete neonatal lethality associated with delayed lung maturation, cyanosis, respiratory distress, atelectasis and decreased surfactant secretion, and show defects in dental epithelial cell differentiation and delayed growth of the lower incisors.

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All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1587
Tissues

502
cDNA Data

89
Literature Summary

59

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA IRX1

Xenbase irx1

ZFIN irx1a, irx1b

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All Sequences

44
RefSeq

4
UniProt

3
CCDS

CCDS26627.1

Ensembl

ENSMUSG00000060969 (Evidence)
NCBI Gene

16371

			Length	Strain/Species	Flank
genomic	16371	NCBI Gene Model \| MGI Sequence Detail	5492	C57BL/6J	± kb
transcript	NM_010573	RefSeq \| MGI Sequence Detail	2080	ZRU/MplStud
polypeptide	P81068	UniProt \| EBI \| MGI Sequence Detail	480	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032290 iroquois-class homeodomain protein IRX-1

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR008422 Homeobox KN domain

IPR009057 Homeobox-like domain superfamily

IPR003893 Iroquois-class homeodomain protein

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All nucleic 100

cDNA 89

Primer pair 5

Other 6

Microarray probesets 4

Summaries

All 97

Developmental Gene Expression 59

Gene Ontology 5

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:354246 Zhu S, et al., Follistatin controls the number of murine teeth by limiting TGF-beta signaling. iScience. 2024 Sep 20;27(9):110785

TSS for Irx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123168	Chr13:72111849-72111874 (-)	-20 bp
Tssr123167	Chr13:72111832-72111848 (-)	2 bp
Tssr123166	Chr13:72111812-72111829 (-)	21 bp
Tssr123165	Chr13:72109821-72109824 (-)	2,019 bp
Tssr123164	Chr13:72108488-72108503 (-)	3,346 bp
Tssr123163	Chr13:72108462-72108476 (-)	3,373 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24