Nrdc MGI Mouse Gene Detail - MGI:1201386

Symbol

Nrdc
Name

nardilysin convertase
Synonyms

MGC:25477, Nrd1, NRD-C

Feature Type

protein coding gene
IDs

MGI:1201386
NCBI Gene: 230598
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr4:108857852-108918974 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 50.77 cM
Mapping Data

1 experiment

SNPs within 2kb

1082 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201386	protein coding gene	Chr4:108857852-108918974 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028566	protein coding gene	Chr4:109762850-109826153 (+)
A/J	MGP_AJ_G0028529	protein coding gene	Chr4:105811745-105873533 (+)
AKR/J	MGP_AKRJ_G0028476	protein coding gene	Chr4:108445901-108508878 (+)
BALB/cJ	MGP_BALBcJ_G0028548	protein coding gene	Chr4:106012485-106082205 (+)
C3H/HeJ	MGP_C3HHeJ_G0028262	protein coding gene	Chr4:109183124-109243737 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028988	protein coding gene	Chr4:113706390-113776036 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026279	protein coding gene	Chr4:101098991-101162585 (+)
CAST/EiJ	MGP_CASTEiJ_G0027698	protein coding gene	Chr4:107037760-107099348 (+)
CBA/J	MGP_CBAJ_G0028231	protein coding gene	Chr4:117437864-117503039 (+)
DBA/2J	MGP_DBA2J_G0028379	protein coding gene	Chr4:105434290-105495064 (+)
FVB/NJ	MGP_FVBNJ_G0028347	protein coding gene	Chr4:104302272-104363745 (+)
LP/J	MGP_LPJ_G0028480	protein coding gene	Chr4:110003266-110070347 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028373	protein coding gene	Chr4:122640434-122703792 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029024	protein coding gene	Chr4:108685936-108749943 (+)
PWK/PhJ	MGP_PWKPhJ_G0027424	protein coding gene	Chr4:103716028-103780245 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027248	protein coding gene	Chr4:106051027-106117101 (+)
WSB/EiJ	MGP_WSBEiJ_G0027779	protein coding gene	Chr4:108862258-108925022 (+)

Human Ortholog

NRDC, nardilysin convertase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NRDC, nardilysin convertase
Synonyms

hNRD1, hNRD2, NRD1
Links

HGNC:7995

NCBI Gene ID: 4898

neXtProt AC: NX_O43847

UniProt: O43847
Chr Location

1p32.3; chr1:51789191-51878805 (-) GRCh38

MGI Vertebrate Homology

Nrdc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NRDC
Gene Tree

Nrdc

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

2
Gene trapped

12
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

4 involving Nrdc
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele mostly die within 48 hours of birth with surviving mice exhibiting cortical thinning, enlarged lateral ventricles, hypomyelination, reduced grip strength, impaired coordination, and impaired spatial working memory.

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All GO Annotations

15
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

58
cDNA Data

18
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nrdc

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All Sequences

68
RefSeq

6
UniProt

7
CCDS

CCDS18460.1, CCDS84773.1, CCDS89800.1

Ensembl

ENSMUSG00000053510 (Evidence)
NCBI Gene

230598

			Length	Strain/Species	Flank
genomic	230598	NCBI Gene Model \| MGI Sequence Detail	61123	C57BL/6J	± kb
transcript	NM_001347169	RefSeq \| MGI Sequence Detail	4529	C57BL/6
polypeptide	Q8BHG1	UniProt \| EBI \| MGI Sequence Detail	1161	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000011421 nardilysin

(term hierarchy)
EC

3.4.24.61
InterPro Domains

IPR011249 Metalloenzyme, LuxS/M16 peptidase-like

IPR050626 Peptidase M16

IPR007863 Peptidase M16, C-terminal

IPR032632 Peptidase M16, middle/third domain

IPR011765 Peptidase M16, N-terminal

IPR001431 Peptidase M16, zinc-binding site
GlyGen

Q8BHG1 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 5

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MGI:2140402, MGI:7469660

Summaries

All 55

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 20
Earliest

J:45959 Fumagalli P, et al., Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. Genomics. 1998 Jan 15;47(2):238-45
Latest

J:347359 Fu J, et al., Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nat Commun. 2024 Apr 11;15(1):3149

TSS for Nrdc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38326	Chr4:108857803-108857903 (+)	1 bp
Tssr38327	Chr4:108858006-108858061 (+)	182 bp
Tssr38328	Chr4:108858095-108858106 (+)	249 bp
Tssr38329	Chr4:108858111-108858122 (+)	265 bp
Tssr38330	Chr4:108858187-108858198 (+)	341 bp
Tssr38331	Chr4:108858251-108858262 (+)	405 bp
Tssr38332	Chr4:108872712-108872720 (+)	14,864 bp
Tssr38333	Chr4:108891053-108891069 (+)	33,209 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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