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Cer1 Gene Detail
Summary
  • Symbol
    Cer1
  • Name
    cerberus 1, DAN family BMP antagonist
  • Synonyms
    cer-1, Cerberus-like, Cerl, Cerl1, Cerr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201414
    NCBI Gene: 12622
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:82799988-82803385 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 39.40 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201414
 protein coding gene Chr4:82799988-82803388 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028400
 protein coding gene Chr4:82454219-82457598 (-)
A/J MGP_AJ_G0028361
 protein coding gene Chr4:79604219-79608507 (-)
AKR/J MGP_AKRJ_G0028310
 protein coding gene Chr4:81664919-81668314 (-)
BALB/cJ MGP_BALBcJ_G0028381
 protein coding gene Chr4:79836579-79839973 (-)
C3H/HeJ MGP_C3HHeJ_G0028096
 protein coding gene Chr4:82250325-82253708 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028820
 protein coding gene Chr4:85719089-85722486 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026120
 protein coding gene Chr4:75557729-75561115 (-)
CAST/EiJ MGP_CASTEiJ_G0027537
 protein coding gene Chr4:80151569-80154955 (-)
CBA/J MGP_CBAJ_G0028065
 protein coding gene Chr4:88380683-88384080 (-)
DBA/2J MGP_DBA2J_G0028214
 protein coding gene Chr4:79375689-79379081 (-)
FVB/NJ MGP_FVBNJ_G0028180
 protein coding gene Chr4:78374056-78377554 (-)
LP/J MGP_LPJ_G0028314
 protein coding gene Chr4:82803816-82807209 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028209
 protein coding gene Chr4:93472580-93475977 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028857
 protein coding gene Chr4:81719021-81722418 (-)
PWK/PhJ MGP_PWKPhJ_G0027260
 protein coding gene Chr4:77720343-77723793 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027085
 protein coding gene Chr4:79244167-79247529 (-)
WSB/EiJ MGP_WSBEiJ_G0027613
 protein coding gene Chr4:81896744-81900133 (-)



Homology
more
  • Human Ortholog
    CER1, cerberus 1, DAN family BMP antagonist
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CER1, cerberus 1, DAN family BMP antagonist
  • Synonyms
    DAND4
  • Links
    NCBI Gene ID: 9350
    neXtProt AC: NX_O95813
    UniProt: O95813

  • Chr Location
    9p22.3; chr9:14717326-14722733 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 6 genetic backgrounds
    29 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for most disruptions in this gene appear normal although one allele displays behavioral abnormalities and a mild increase in body weight with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1223
  • Tissues
    198
  • cDNA Data
    23
  • Literature Summary
    214
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038192 Ensembl Gene Model | MGI Sequence Detail 3398 C57BL/6J ±  kb
    transcript ENSMUST00000048430 Ensembl | MGI Sequence Detail 1739 Not Applicable  
    polypeptide ENSMUSP00000048607 Ensembl | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 1
      cDNA 28
      Primer pair 9
      Other 21

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:894319
    References
    more
    • Summaries
      All 256
      Developmental Gene Expression 214
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:44900 Belo JA, et al., Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev. 1997 Nov;68(1-2):45-57
    • Latest
      J:353553 Despin-Guitard E, et al., Non-apical mitoses contribute to cell delamination during mouse gastrulation. Nat Commun. 2024 Aug 28;15(1):7364
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory