Hrk MGI Mouse Gene Detail - MGI:1201608 - harakiri, BCL2 interacting protein (contains only BH3 domain)

Symbol

Hrk
Name

harakiri, BCL2 interacting protein (contains only BH3 domain)
Synonyms

Bid3, DP5

Feature Type

protein coding gene
IDs

MGI:1201608
NCBI Gene: 12123
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr5:118307829-118327543 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 58.16 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

482 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201608	protein coding gene	Chr5:118302713-118327543 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029994	protein coding gene	Chr5:121318913-121346479 (+)
A/J	MGP_AJ_G0029958	protein coding gene	Chr5:116358773-116385047 (+)
AKR/J	MGP_AKRJ_G0029897	protein coding gene	Chr5:120114037-120143790 (+)
BALB/cJ	MGP_BALBcJ_G0029969	protein coding gene	Chr5:117782651-117809236 (+)
C3H/HeJ	MGP_C3HHeJ_G0029689	protein coding gene	Chr5:120649474-120677550 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030424	protein coding gene	Chr5:125919826-125949484 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027650	protein coding gene	Chr5:111118640-111143566 (+)
CAST/EiJ	MGP_CASTEiJ_G0029098	protein coding gene	Chr5:119668366-119693918 (+)
CBA/J	MGP_CBAJ_G0029657	protein coding gene	Chr5:130772735-130799892 (+)
DBA/2J	MGP_DBA2J_G0029807	protein coding gene	Chr5:116457559-116482983 (+)
FVB/NJ	MGP_FVBNJ_G0029763	protein coding gene	Chr5:115356096-115381845 (+)
LP/J	MGP_LPJ_G0029895	protein coding gene	Chr5:121806672-121835155 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029794	protein coding gene	Chr5:134942810-134972440 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030465	protein coding gene	Chr5:119669539-119697011 (+)
PWK/PhJ	MGP_PWKPhJ_G0028811	protein coding gene	Chr5:115168541-115195419 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028649	protein coding gene	Chr5:117258379-117286786 (+)
WSB/EiJ	MGP_WSBEiJ_G0029173	protein coding gene	Chr5:120239733-120271924 (+)

Human Ortholog

HRK, harakiri, BCL2 interacting protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HRK, harakiri, BCL2 interacting protein
Synonyms

DP5, HARAKIRI
Links

HGNC:5185

NCBI Gene ID: 8739

neXtProt AC: NX_O00198

UniProt: O00198
Chr Location

12q24.22; chr12:116856144-116881441 (-) GRCh38

MGI Vertebrate Homology

Hrk stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HRK
Protein SuperFamily

BID3
Gene Tree

Hrk

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Hrk
Find Mice (IMSR)

0 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants exhibit motoneurons that are protected from cell death induced by resection of the hypoglossal nerve and delayed cell death of superior cervical ganglia neurons triggered by nerve growth factor withdrawal.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

39
cDNA Data

12
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS39236.1

Ensembl

ENSMUSG00000046607 (Evidence)
NCBI Gene

12123

			Length	Strain/Species	Flank
genomic	12123	NCBI Gene Model \| MGI Sequence Detail	19715	C57BL/6J	± kb
transcript	NM_007545	RefSeq \| MGI Sequence Detail	5366	Not Specified
polypeptide	P62816	UniProt \| EBI \| MGI Sequence Detail	92	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008752 activator of apoptosis harakiri

(term hierarchy)
InterPro Domains

IPR017249 Activator of apoptosis harakiri

IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site

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All nucleic 15

cDNA 13

Primer pair 2

Microarray probesets 4

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MGI:2140973

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:342802 Wang N, et al., Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Neuron. 2022 Oct 19;110(20):3318-3338.e9

TSS for Hrk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48417	Chr5:118307777-118307808 (+)	-36 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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