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Mfsd14a Gene Detail
Summary
  • Symbol
    Mfsd14a
  • Name
    major facilitator superfamily domain containing 14A
  • Synonyms
    Hiat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201609
    NCBI Gene: 15247
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:116424813-116456264 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 50.42 cM, cytoband G2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    818 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201609
 protein coding gene Chr3:116424813-116456326 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027815
 protein coding gene Chr3:118540851-118572142 (-)
A/J MGP_AJ_G0027773
 protein coding gene Chr3:114659935-114691572 (-)
AKR/J MGP_AKRJ_G0027739
 protein coding gene Chr3:117566755-117598276 (-)
BALB/cJ MGP_BALBcJ_G0027785
 protein coding gene Chr3:114501968-114533550 (-)
C3H/HeJ MGP_C3HHeJ_G0027516
 protein coding gene Chr3:117924580-117957510 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028231
 protein coding gene Chr3:122889533-122921026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025570
 protein coding gene Chr3:110348876-110378850 (-)
CAST/EiJ MGP_CASTEiJ_G0026972
 protein coding gene Chr3:117210506-117242194 (-)
CBA/J MGP_CBAJ_G0027491
 protein coding gene Chr3:127081067-127115231 (-)
DBA/2J MGP_DBA2J_G0027632
 protein coding gene Chr3:113897705-113929037 (-)
FVB/NJ MGP_FVBNJ_G0027600
 protein coding gene Chr3:111534615-111565807 (-)
LP/J MGP_LPJ_G0027742
 protein coding gene Chr3:120082849-120116177 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027630
 protein coding gene Chr3:134466201-134499074 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028287
 protein coding gene Chr3:117101278-117134071 (-)
PWK/PhJ MGP_PWKPhJ_G0026698
 protein coding gene Chr3:113542582-113574375 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026520
 protein coding gene Chr3:115110999-115148629 (-)
WSB/EiJ MGP_WSBEiJ_G0027052
 protein coding gene Chr3:117784568-117816116 (-)



Homology
more
  • Human Ortholog
    MFSD14A, major facilitator superfamily domain containing 14A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MFSD14A, major facilitator superfamily domain containing 14A
  • Synonyms
    HAIT1, HIAT1
  • Links
    NCBI Gene ID: 64645
    neXtProt AC: NX_Q96MC6
    UniProt: Q96MC6

  • Chr Location
    1p21.2; chr1:100038095-100083377 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility with oligozoospermia, globozoospermia, and defects in spermiogenesis and acrosome formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    15
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15247 NCBI Gene Model | MGI Sequence Detail 31452 C57BL/6J ±  kb
    transcript NM_001410019 RefSeq | MGI Sequence Detail 2768 C57BL/6  
    polypeptide P70187 UniProt | EBI | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008546 hippocampus abundant transcript 1 protein
      (term hierarchy)
    • InterPro Domains
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR005829 Sugar transporter, conserved site
      IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG-like
    • GlyGen
      P70187 2 sites
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 4
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:42916 Matsuo N, et al., Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus. Biochem Biophys Res Commun. 1997 Sep 8;238(1):126-9
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory