Cxadr MGI Mouse Gene Detail - MGI:1201679 - coxsackie virus and adenovirus receptor

Symbol

Cxadr
Name

coxsackie virus and adenovirus receptor
Synonyms

2610206D03Rik, CAR, MCAR, MCVADR

Feature Type

protein coding gene
IDs

MGI:1201679
NCBI Gene: 13052
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:78098377-78156662 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 45.28 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

1785 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201679	protein coding gene	Chr16:78098114-78156673 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022960	protein coding gene	Chr16:78461491-78519279 (+)
A/J	MGP_AJ_G0022928	protein coding gene	Chr16:75009487-75060638 (+)
AKR/J	MGP_AKRJ_G0022898	protein coding gene	Chr16:77259677-77315014 (+)
BALB/cJ	MGP_BALBcJ_G0022930	protein coding gene	Chr16:75407397-75463324 (+)
C3H/HeJ	MGP_C3HHeJ_G0022692	protein coding gene	Chr16:77706795-77759057 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023378	protein coding gene	Chr16:80993695-81050346 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020881	protein coding gene	Chr16:73437359-73488074 (+)
CAST/EiJ	MGP_CASTEiJ_G0022214	protein coding gene	Chr16:78114763-78168000 (+)
CBA/J	MGP_CBAJ_G0022662	protein coding gene	Chr16:84428828-84485339 (+)
DBA/2J	MGP_DBA2J_G0022795	protein coding gene	Chr16:74844026-74895547 (+)
FVB/NJ	MGP_FVBNJ_G0022770	protein coding gene	Chr16:74189587-74240817 (+)
LP/J	MGP_LPJ_G0022864	protein coding gene	Chr16:78200637-78253575 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022789	protein coding gene	Chr16:87682509-87738511 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023395	protein coding gene	Chr16:77579810-77632471 (+)
PWK/PhJ	MGP_PWKPhJ_G0021956	protein coding gene	Chr16:75049937-75101952 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021786	protein coding gene	Chr16:77263147-77320610 (+)
WSB/EiJ	MGP_WSBEiJ_G0022262	protein coding gene	Chr16:77824033-77878242 (+)

Human Ortholog

CXADR, CXADR Ig-like cell adhesion molecule

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXADR, CXADR Ig-like cell adhesion molecule
Synonyms

CAR, CAR4/6, HCAR
Links

HGNC:2559

NCBI Gene ID: 1525

neXtProt AC: NX_P78310

UniProt: P78310
Chr Location

21q21.1; chr21:17513043-17636262 (+) GRCh38

MGI Vertebrate Homology

Cxadr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CXADR
Gene Tree

Cxadr

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References

1 with disease annotations

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Phenotype Summary

66 phenotypes from 10 alleles in 12 genetic backgrounds
3 images
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

3
Gene trapped

3
Targeted

13
Transgenic

1
Genomic Mutations

4 involving Cxadr
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display embryonic lethality with focal cardiomyocyte apoptosis and extensive thoracic hemorrhaging.

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All GO Annotations

90
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1442
Tissues

225
cDNA Data

189
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cxadr

ZFIN cxadr

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All Sequences

80
RefSeq

14
UniProt

4
CCDS

CCDS28276.1, CCDS37379.1, CCDS88952.1

Ensembl

ENSMUSG00000022865 (Evidence)
NCBI Gene

13052

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022865	Ensembl Gene Model \| MGI Sequence Detail	58286	C57BL/6J	± kb
transcript	ENSMUST00000023572	Ensembl \| MGI Sequence Detail	5742	Not Applicable
polypeptide	ENSMUSP00000023572	Ensembl \| MGI Sequence Detail	365	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006062 coxsackievirus and adenovirus receptor

(term hierarchy)
PDB

3JZ7, 3MJ7
InterPro Domains

IPR052307 Epithelial Junction Adhesion Regulator

IPR013151 Immunoglobulin

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain
GlyGen

P97792 4 sites, 4 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 206

Genomic 1

cDNA 189

Primer pair 14

Other 2

Microarray probesets 9

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MGI:1917696, MGI:2146546, MGI:2146662

Summaries

All 116

Developmental Gene Expression 25

Diseases 1

Gene Ontology 21

Phenotypes 48
Earliest

J:51751 Tomko RP, et al., HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3352-6
Latest

J:358811 Kim HG, et al., Liver-specific Coxsackievirus and adenovirus receptor deletion develop metabolic dysfunction-associated fatty liver disease. Sci Rep. 2024 Sep 16;14(1):21642

TSS for Cxadr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139118	Chr16:78098346-78098369 (+)	-19 bp
Tssr139119	Chr16:78098561-78098648 (+)	228 bp
Tssr139120	Chr16:78098663-78098692 (+)	301 bp
Tssr139121	Chr16:78099432-78099436 (+)	1,057 bp
Tssr139122	Chr16:78106428-78106439 (+)	8,057 bp
Tssr139123	Chr16:78106440-78106452 (+)	8,069 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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