Kif20a MGI Mouse Gene Detail - MGI:1201682

Symbol

Kif20a
Name

kinesin family member 20A
Synonyms

Rab6kifl, Rabkinesin-6

Feature Type

protein coding gene
IDs

MGI:1201682
NCBI Gene: 19348
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr18:34757677-34766330 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 18.69 cM
Mapping Data

3 experiments

SNPs within 2kb

260 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201682	protein coding gene	Chr18:34757666-34766330 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024245	protein coding gene	Chr18:32847220-32854809 (+)
A/J	MGP_AJ_G0024211	protein coding gene	Chr18:31739250-31746936 (+)
AKR/J	MGP_AKRJ_G0024180	protein coding gene	Chr18:32642876-32650613 (+)
BALB/cJ	MGP_BALBcJ_G0024211	protein coding gene	Chr18:31796352-31803940 (+)
C3H/HeJ	MGP_C3HHeJ_G0023979	protein coding gene	Chr18:32658872-32667479 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024653	protein coding gene	Chr18:34108029-34115594 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022094	protein coding gene	Chr18:31880036-31887579 (+)
CAST/EiJ	MGP_CASTEiJ_G0023454	protein coding gene	Chr18:32607539-32615082 (+)
CBA/J	MGP_CBAJ_G0023947	protein coding gene	Chr18:35043785-35053537 (+)
DBA/2J	MGP_DBA2J_G0024079	protein coding gene	Chr18:31394312-31402177 (+)
FVB/NJ	MGP_FVBNJ_G0024045	protein coding gene	Chr18:31080184-31087771 (+)
LP/J	MGP_LPJ_G0024160	protein coding gene	Chr18:32929981-32938908 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024073	protein coding gene	Chr18:36309500-36317093 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024701	protein coding gene	Chr18:32470121-32477871 (+)
PWK/PhJ	MGP_PWKPhJ_G0023197	protein coding gene	Chr18:31585437-31593203 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023006	protein coding gene	Chr18:32742300-32750800 (+)
WSB/EiJ	MGP_WSBEiJ_G0023517	protein coding gene	Chr18:32390397-32398465 (+)

Human Ortholog

KIF20A, kinesin family member 20A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF20A, kinesin family member 20A
Synonyms

MKLP2, RAB6KIFL, RCM6
Links

HGNC:9787

NCBI Gene ID: 10112

neXtProt AC: NX_O95235

UniProt: O95235
Chr Location

5q31.2; chr5:138178719-138187723 (+) GRCh38

MGI Vertebrate Homology

Kif20a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF20A
Gene Tree

Kif20a

Diseases

1 with human KIF20A associations

				Human Disease	Mouse Models
				restrictive cardiomyopathy IDs restrictive cardiomyopathy DOID:397 ICD10CM:I42.5 MESH:D002313 NCI:C62798 OMIM:115210 OMIM:PS115210 ORDO:75249 UMLS_CUI:C0007196

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Gene trapped

21
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

774
Tissues

14
cDNA Data

15
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KIF20A

Xenbase kif20a

ZFIN kif20a

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All Sequences

53
RefSeq

6
UniProt

3
CCDS

CCDS29131.1

Ensembl

ENSMUSG00000003779 (Evidence)
NCBI Gene

19348

			Length	Strain/Species	Flank
genomic	19348	NCBI Gene Model \| MGI Sequence Detail	8654	C57BL/6J	± kb
transcript	NM_001166406	RefSeq \| MGI Sequence Detail	3579	ZRU/MplStud
polypeptide	P97329	UniProt \| EBI \| MGI Sequence Detail	887	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009298 kinesin-like protein KIF20A

(term hierarchy)
PDB

5LEF, 5ND2, 5ND3, 5ND4, 5ND7, 8BJS, 8F18, 8F1A
InterPro Domains

IPR027640 Kinesin-like protein

IPR047149 Kinesin-like protein KIF11-like

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 21

cDNA 19

Primer pair 2

Microarray probesets 4

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MGI:2147172

Summaries

All 51

Developmental Gene Expression 9

Gene Ontology 7

Phenotypes 13
Earliest

J:45570 Echard A, et al., Interaction of a Golgi-associated kinesin-like protein with Rab6. Science. 1998 Jan 23;279(5350):580-5
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kif20a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150465	Chr18:34757674-34757682 (+)	1 bp
Tssr150466	Chr18:34757687-34757715 (+)	24 bp
Tssr150467	Chr18:34758008-34758053 (+)	354 bp
Tssr150468	Chr18:34758062-34758084 (+)	396 bp
Tssr150469	Chr18:34758095-34758106 (+)	424 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24