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Fxyd5 Gene Detail
Summary
  • Symbol
    Fxyd5
  • Name
    FXYD domain-containing ion transport regulator 5
  • Synonyms
    dysadherin, EF-8, Oit2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201785
    NCBI Gene: 18301
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30732153-30741565 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201785
 protein coding gene Chr7:30732147-30741906 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032056
 protein coding gene Chr7:30091140-30101401 (-)
A/J MGP_AJ_G0032033
 protein coding gene Chr7:29279813-29290581 (-)
AKR/J MGP_AKRJ_G0031966
 protein coding gene Chr7:30015921-30027357 (-)
BALB/cJ MGP_BALBcJ_G0032040
 protein coding gene Chr7:29455842-29465980 (-)
C3H/HeJ MGP_C3HHeJ_G0031757
 protein coding gene Chr7:30481113-30490796 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032506
 protein coding gene Chr7:31098668-31110566 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029556
 protein coding gene Chr7:30234756-30244629 (-)
CAST/EiJ MGP_CASTEiJ_G0031093
 protein coding gene Chr7:23728368-23738011 (-)
CBA/J MGP_CBAJ_G0031725
 protein coding gene Chr7:32554464-32569813 (-)
DBA/2J MGP_DBA2J_G0031877
 protein coding gene Chr7:28991340-29005686 (-)
FVB/NJ MGP_FVBNJ_G0031833
 protein coding gene Chr7:29114642-29124343 (-)
LP/J MGP_LPJ_G0031958
 protein coding gene Chr7:30431599-30441280 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031870
 protein coding gene Chr7:31784981-31794677 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032532
 protein coding gene Chr7:29530715-29539985 (-)
PWK/PhJ MGP_PWKPhJ_G0030815
 protein coding gene Chr7:24030311-24040014 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030652
 protein coding gene Chr7:20518546-20528802 (-)
WSB/EiJ MGP_WSBEiJ_G0031203
 protein coding gene Chr7:29934581-29944367 (-)



Homology
more
  • Human Ortholog
    FXYD5, FXYD domain containing ion transport regulator 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FXYD5, FXYD domain containing ion transport regulator 5
  • Synonyms
    DYSAD, HSPC113, IWU1, KCT1, OIT2, PRO6241, RIC
  • Links
    NCBI Gene ID: 53827
    neXtProt AC: NX_Q96DB9
    UniProt: Q96DB9

  • Chr Location
    19q13.12; chr19:35154730-35171791 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit resistance to AOS/DSS-and APC knockout-induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    15
  • cDNA Data
    49
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18301 NCBI Gene Model | MGI Sequence Detail 9413 C57BL/6J ±  kb
transcript NM_001111073 RefSeq | MGI Sequence Detail 1090 C57BL/6  
polypeptide P97808 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 49

    Microarray probesets 3
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
  • Latest
    J:331268 Ding Y, et al., A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Elife. 2022 Oct 18;11
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory