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Socs2 Gene Detail
Summary
  • Symbol
    Socs2
  • Name
    suppressor of cytokine signaling 2
  • Synonyms
    CIS2, Cish2, cytokine-inducible SH2 protein 2, D130043N08Rik, JAB, SOCS-2, SSI-2, STAT-induced STAT inhibitor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201787
    NCBI Gene: 216233
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:95221224-95253042 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 49.35 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    881 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201787
 protein coding gene Chr10:95219765-95253176 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017668
 protein coding gene Chr10:96937501-96973758 (-)
A/J MGP_AJ_G0017647
 protein coding gene Chr10:93528011-93558876 (-)
AKR/J MGP_AKRJ_G0017605
 protein coding gene Chr10:96199180-96236042 (-)
BALB/cJ MGP_BALBcJ_G0017610
 protein coding gene Chr10:93794557-93824412 (-)
C3H/HeJ MGP_C3HHeJ_G0017433
 protein coding gene Chr10:96199525-96231133 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018067
 protein coding gene Chr10:100150125-100185147 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015748
 protein coding gene Chr10:89086325-89118747 (-)
CAST/EiJ MGP_CASTEiJ_G0016998
 protein coding gene Chr10:96209855-96244430 (-)
CBA/J MGP_CBAJ_G0017402
 protein coding gene Chr10:104278647-104312833 (-)
DBA/2J MGP_DBA2J_G0017508
 protein coding gene Chr10:92619652-92650802 (-)
FVB/NJ MGP_FVBNJ_G0017500
 protein coding gene Chr10:91864714-91898012 (-)
LP/J MGP_LPJ_G0017582
 protein coding gene Chr10:97560945-97597764 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017531
 protein coding gene Chr10:105462343-105494616 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018104
 protein coding gene Chr10:96107136-96138829 (-)
PWK/PhJ MGP_PWKPhJ_G0016779
 protein coding gene Chr10:92724080-92757281 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016567
 protein coding gene Chr10:94940896-94972139 (-)
WSB/EiJ MGP_WSBEiJ_G0017057
 protein coding gene Chr10:96078253-96116025 (-)



Homology
more
  • Human Ortholog
    SOCS2, suppressor of cytokine signaling 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOCS2, suppressor of cytokine signaling 2
  • Synonyms
    CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
  • Links
    NCBI Gene ID: 8835
    neXtProt AC: NX_O14508
    UniProt: O14508

  • Chr Location
    12q22; chr12:93569814-93626236 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SOCS2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 4 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene cause accelerated postnatal growth. Homozygotes for a targeted mutation also show increased bone growth, enlargement of most organs, collagen deposition in the skin and some ducts and vessels, lower major urinary protein levels, and elevated IGF-I mRNA levels in some tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    20
  • cDNA Data
    19
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020027 Ensembl Gene Model | MGI Sequence Detail 31819 C57BL/6J ±  kb
    transcript ENSMUST00000139210 Ensembl | MGI Sequence Detail 4242 Not Applicable  
    polypeptide ENSMUSP00000121305 Ensembl | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10702, MGI:2143636, MGI:2143807, MGI:96077
    References
    more
    • Summaries
      All 153
      Developmental Gene Expression 12
      Gene Ontology 13
      Phenotypes 77
    • Earliest
      J:220665 Bradford GE, Selection for litter size in mice in the presence and absence of gonadotropin treatment. Genetics. 1968 Feb;58(2):283-95
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory