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Socs3 Gene Detail
Summary
  • Symbol
    Socs3
  • Name
    suppressor of cytokine signaling 3
  • Synonyms
    CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201791
    NCBI Gene: 12702
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117856905-117860192 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 82.96 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201791
 protein coding gene Chr11:117856905-117860873 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019459
 protein coding gene Chr11:122266035-122270003 (-)
A/J MGP_AJ_G0019427
 protein coding gene Chr11:116842490-116846524 (-)
AKR/J MGP_AKRJ_G0019397
 protein coding gene Chr11:120396236-120400204 (-)
BALB/cJ MGP_BALBcJ_G0019402
 protein coding gene Chr11:117211260-117215228 (-)
C3H/HeJ MGP_C3HHeJ_G0019208
 protein coding gene Chr11:120691033-120695001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019851
 protein coding gene Chr11:126002985-126006953 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017476
 protein coding gene Chr11:113853358-113857332 (-)
CAST/EiJ MGP_CASTEiJ_G0018762
 protein coding gene Chr11:122103875-122110862 (-)
CBA/J MGP_CBAJ_G0019179
 protein coding gene Chr11:130936866-130940834 (-)
DBA/2J MGP_DBA2J_G0019291
 protein coding gene Chr11:116236796-116240764 (-)
FVB/NJ MGP_FVBNJ_G0019283
 protein coding gene Chr11:115864570-115868540 (-)
LP/J MGP_LPJ_G0019361
 protein coding gene Chr11:122587007-122590975 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019316
 protein coding gene Chr11:129906322-129910292 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019890
 protein coding gene Chr11:121048334-121052302 (-)
PWK/PhJ MGP_PWKPhJ_G0018528
 protein coding gene Chr11:117598422-117605406 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018320
 protein coding gene Chr11:120775916-120779885 (-)
WSB/EiJ MGP_WSBEiJ_G0018814
 protein coding gene Chr11:121010047-121014016 (-)



Homology
more
  • Human Ortholog
    SOCS3, suppressor of cytokine signaling 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOCS3, suppressor of cytokine signaling 3
  • Synonyms
    ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3
  • Links
    NCBI Gene ID: 9021
    neXtProt AC: NX_O14543
    UniProt: O14543

  • Chr Location
    17q25.3; chr17:78356778-78360925 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SOCS3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 7 alleles in 9 genetic backgrounds
    162 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations cause impairment if gene expression show immunological and hematopoetic abnormalities. Complete gene disruption causes lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    23
  • cDNA Data
    54
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12702 NCBI Gene Model | MGI Sequence Detail 3288 C57BL/6J ±  kb
    transcript NM_007707 RefSeq | MGI Sequence Detail 2742 C57BL/6  
    polypeptide O35718 UniProt | EBI | MGI Sequence Detail 225 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 54
      Primer pair 4

      Microarray probesets 7
    References
    more
    • Summaries
      All 321
      Developmental Gene Expression 18
      Gene Ontology 17
      Phenotypes 162
    • Earliest
      J:42258 Minamoto S, et al., Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem Biophys Res Commun. 1997 Aug 8;237(1):79-83
    • Latest
      J:355492 Gu X, et al., MiR-9 promotes G-MDSC recruitment and tumor proliferation by targeting SOCS3 in breast cancer. FASEB J. 2024 Jan;38(1):e23388
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory