Phlda2 MGI Mouse Gene Detail - MGI:1202307 - pleckstrin homology like domain, family A, member 2

Symbol

Phlda2
Name

pleckstrin homology like domain, family A, member 2
Synonyms

Ipl, Tssc3

Feature Type

protein coding gene
IDs

MGI:1202307
NCBI Gene: 22113
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:143055282-143056882 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 88.23 cM
Mapping Data

14 experiments

SNPs within 2kb

80 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1202307	protein coding gene	Chr7:143055282-143056887 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033274	protein coding gene	Chr7:148800509-148801505 (-)
A/J	MGP_AJ_G0033257	protein coding gene	Chr7:144484246-144485242 (-)
AKR/J	MGP_AKRJ_G0033188	protein coding gene	Chr7:148534714-148535710 (-)
BALB/cJ	MGP_BALBcJ_G0033257	protein coding gene	Chr7:144269401-144270397 (-)
C3H/HeJ	MGP_C3HHeJ_G0032973	protein coding gene	Chr7:148299164-148300160 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033767	protein coding gene	Chr7:154171266-154172262 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030740	protein coding gene	Chr7:145703395-145704391 (-)
CAST/EiJ	MGP_CASTEiJ_G0032295	protein coding gene	Chr7:140617002-140617998 (-)
CBA/J	MGP_CBAJ_G0032944	protein coding gene	Chr7:159429547-159430543 (-)
DBA/2J	MGP_DBA2J_G0033098	protein coding gene	Chr7:142457844-142458840 (-)
FVB/NJ	MGP_FVBNJ_G0033046	protein coding gene	Chr7:142391409-142392405 (-)
LP/J	MGP_LPJ_G0033190	protein coding gene	Chr7:150322459-150323455 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033080	protein coding gene	Chr7:160024084-160025080 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033787	protein coding gene	Chr7:147511345-147512341 (-)
PWK/PhJ	MGP_PWKPhJ_G0032004	protein coding gene	Chr7:135770607-135771603 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031850	protein coding gene	Chr7:134316424-134317420 (-)
WSB/EiJ	MGP_WSBEiJ_G0032407	protein coding gene	Chr7:148506896-148507892 (-)

Human Ortholog

PHLDA2, pleckstrin homology like domain family A member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHLDA2, pleckstrin homology like domain family A member 2
Synonyms

BRW1C, BWR1C, HLDA2, IPL, TSSC3
Links

HGNC:12385

NCBI Gene ID: 7262

neXtProt AC: NX_Q53GA4

UniProt: Q53GA4
Chr Location

11p15.4; chr11:2928273-2929420 (-) GRCh38

MGI Vertebrate Homology

Phlda2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PHLDA2
Gene Tree

Phlda2

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Mutations/Alleles

3 with disease annotations

References

3 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 1 genetic background
28 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

3
Targeted

5
Transgenic

3
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene have enlarged placentas but display little change in fetal weight.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

946
Tissues

111
cDNA Data

39
Literature Summary

45

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PHLDA2

Xenbase phlda2

ZFIN phlda2

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All Sequences

39
RefSeq

4
UniProt

2
CCDS

CCDS22042.1

Ensembl

ENSMUSG00000010760 (Evidence)
NCBI Gene

22113

			Length	Strain/Species	Flank
genomic	22113	NCBI Gene Model \| MGI Sequence Detail	1601	C57BL/6J	± kb
transcript	NM_009434	RefSeq \| MGI Sequence Detail	737	C57BL/6 x DBA
polypeptide	O08969	UniProt \| EBI \| MGI Sequence Detail	144	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012664 pleckstrin homology-like domain family A member 2

(term hierarchy)
InterPro Domains

IPR042832 PHLDA family

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 65

Genomic 11

cDNA 40

Primer pair 10

Other 4

Microarray probesets 3

Summaries

All 93

Developmental Gene Expression 45

Diseases 3

Gene Ontology 6

Phenotypes 21
Earliest

J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
Latest

J:351979 Yang X, et al., PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression. Cell Metab. 2024 Jan 29;

TSS for Phlda2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75950	Chr7:143056491-143056530 (-)	371 bp
Tssr75949	Chr7:143056252-143056269 (-)	621 bp
Tssr75948	Chr7:143055857-143055885 (-)	1,011 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24