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Mmp8 Gene Detail
Summary
  • Symbol
    Mmp8
  • Name
    matrix metallopeptidase 8
  • Synonyms
    Collagenase-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202395
    NCBI Gene: 17394
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7558457-7568486 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    447 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202395
 protein coding gene Chr9:7558430-7568487 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034324
 protein coding gene Chr9:4420807-4430841 (+)
A/J MGP_AJ_G0034302
 protein coding gene Chr9:4525622-4535679 (+)
AKR/J MGP_AKRJ_G0034230
 protein coding gene Chr9:4391085-4401125 (+)
BALB/cJ MGP_BALBcJ_G0034296
 protein coding gene Chr9:4257417-4267430 (+)
C3H/HeJ MGP_C3HHeJ_G0034007
 protein coding gene Chr9:4592615-4602660 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034818
 protein coding gene Chr9:4593026-4603075 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031756
 protein coding gene Chr9:3783613-3793566 (+)
CAST/EiJ MGP_CASTEiJ_G0033335
 protein coding gene Chr9:4602962-4617220 (+)
CBA/J MGP_CBAJ_G0033980
 protein coding gene Chr9:4692608-4702653 (+)
DBA/2J MGP_DBA2J_G0034137
 protein coding gene Chr9:4403245-4413298 (+)
FVB/NJ MGP_FVBNJ_G0034082
 protein coding gene Chr9:4179682-4189711 (+)
LP/J MGP_LPJ_G0034223
 protein coding gene Chr9:4470940-4480980 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034126
 protein coding gene Chr9:5427256-5438757 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034837
 protein coding gene Chr9:4388371-4398447 (+)
PWK/PhJ MGP_PWKPhJ_G0033038
 protein coding gene Chr9:4523751-4534715 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032876
 protein coding gene Chr9:4638491-4647894 (+)
WSB/EiJ MGP_WSBEiJ_G0033450
 protein coding gene Chr9:4403632-4413690 (+)



Homology
more
  • Human Ortholog
    MMP8, matrix metallopeptidase 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP8, matrix metallopeptidase 8
  • Synonyms
    CLG1, HNC, MMP-8, PMNL-CL
  • Links
    NCBI Gene ID: 4317
    neXtProt AC: NX_P22894
    UniProt: P22894

  • Chr Location
    11q22.2; chr11:102711796-102727050 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MMP8 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males, and to a lesser extent ovariectomized or tamoxifen-treated null females, show increased susceptibility to chemically-induced skin tumors, a sustained inflammatory response to carcinogens, and increased PMN burden in the alveolar space during LPS-mediated acute lung injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    947
  • Tissues
    50
  • cDNA Data
    19
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005800 Ensembl Gene Model | MGI Sequence Detail 10030 C57BL/6J ±  kb
    transcript ENSMUST00000018765 Ensembl | MGI Sequence Detail 2425 Not Applicable  
    polypeptide ENSMUSP00000018765 Ensembl | MGI Sequence Detail 465 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 3
      cDNA 21
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143366
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 23
      Gene Ontology 10
      Phenotypes 44
    • Earliest
      J:46612 Lawson ND, et al., Isolation and characterization of the cDNA for mouse neutrophil collagenase: demonstration of shared negative regulatory pathways for neutrophil secondary granule protein gene expression. Blood. 1998 Apr 1;91(7):2517-24
    • Latest
      J:352325 Cathomas F, et al., Circulating myeloid-derived MMP8 in stress susceptibility and depression. Nature. 2024 Feb;626(8001):1108-1115
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory