Ints6 MGI Mouse Gene Detail - MGI:1202397 - integrator complex subunit 6

Symbol

Ints6
Name

integrator complex subunit 6
Synonyms

2900075H24Rik, Ddx26, DICE1, Notch2l

Feature Type

protein coding gene
IDs

MGI:1202397
NCBI Gene: 18130
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:62913779-62998618 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 33.23 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

1600 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1202397	protein coding gene	Chr14:62913774-62998618 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021449	protein coding gene	Chr14:57134210-57224103 (-)
A/J	MGP_AJ_G0021408	protein coding gene	Chr14:55848408-55934252 (-)
AKR/J	MGP_AKRJ_G0021384	protein coding gene	Chr14:57848447-57935388 (-)
BALB/cJ	MGP_BALBcJ_G0021414	protein coding gene	Chr14:55808307-55893843 (-)
C3H/HeJ	MGP_C3HHeJ_G0021191	protein coding gene	Chr14:57476270-57563379 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021853	protein coding gene	Chr14:59878165-59965010 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019393	protein coding gene	Chr14:53812725-53898780 (-)
CAST/EiJ	MGP_CASTEiJ_G0020708	protein coding gene	Chr14:53911020-53998773 (-)
CBA/J	MGP_CBAJ_G0021158	protein coding gene	Chr14:61614407-61705444 (-)
DBA/2J	MGP_DBA2J_G0021281	protein coding gene	Chr14:55518193-55603406 (-)
FVB/NJ	MGP_FVBNJ_G0021260	protein coding gene	Chr14:54932573-55017863 (-)
LP/J	MGP_LPJ_G0021356	protein coding gene	Chr14:58174342-58259560 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021289	protein coding gene	Chr14:60920395-61012194 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021876	protein coding gene	Chr14:56993383-57079740 (-)
PWK/PhJ	MGP_PWKPhJ_G0020452	protein coding gene	Chr14:52198414-52284477 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020285	protein coding gene	Chr14:52971162-53055778 (-)
WSB/EiJ	MGP_WSBEiJ_G0020761	protein coding gene	Chr14:57312047-57398127 (-)

Human Ortholog

INTS6, integrator complex subunit 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INTS6, integrator complex subunit 6
Synonyms

DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2
Links

HGNC:14879

NCBI Gene ID: 26512

neXtProt AC: NX_Q9UL03

UniProt: Q9UL03
Chr Location

13q14.3; chr13:51334405-51454264 (-) GRCh38

MGI Vertebrate Homology

Ints6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: INTS6
Gene Tree

Ints6

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

90
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

87
Transgenic

1
Genomic Mutations

1 involving Ints6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

90 strains or lines available

Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

6
cDNA Data

14
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ints6

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All Sequences

65
RefSeq

18
UniProt

2
CCDS

CCDS27191.1

Ensembl

ENSMUSG00000035161 (Evidence)
NCBI Gene

18130

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035161	Ensembl Gene Model \| MGI Sequence Detail	84840	C57BL/6J	± kb
transcript	ENSMUST00000053959	Ensembl \| MGI Sequence Detail	4993	Not Applicable
polypeptide	ENSMUSP00000086788	Ensembl \| MGI Sequence Detail	883	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009075 integrator complex subunit 6

(term hierarchy)
InterPro Domains

IPR051113 Integrator complex subunit 6

IPR029307 INTS6/SAGE1/DDX26B/CT45, C-terminal

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A
GlyGen

Q6PCM2 1 site, 1 O-linked glycan (1 site)

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All nucleic 17

cDNA 17

Microarray probesets 6

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MGI:1920288, MGI:2145666

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 12
Earliest

J:45989 Hoff HB 3rd, et al., DBI-1, a novel gene related to the notch family, modulates mitogenic response to insulin-like growth factor 1. Exp Cell Res. 1998 Feb 1;238(2):359-70
Latest

J:169836 Lachke SA, et al., Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25;331(6024):1571-6

TSS for Ints6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129116	Chr14:62998576-62998594 (-)	33 bp
Tssr4448	Chr14:62998561-62998570 (-)	52 bp
Tssr129115	Chr14:62998337-62998350 (-)	274 bp
Tssr129114	Chr14:62938103-62938150 (-)	60,491 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24