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Tert Gene Detail
Summary
  • Symbol
    Tert
  • Name
    telomerase reverse transcriptase
  • Synonyms
    TR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202709
    NCBI Gene: 21752
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:73775030-73797962 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 40.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    753 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202709
 protein coding gene Chr13:73775030-73797962 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020748
 protein coding gene Chr13:74082983-74107608 (+)
A/J MGP_AJ_G0020704
 protein coding gene Chr13:71447412-71471070 (+)
AKR/J MGP_AKRJ_G0020678
 protein coding gene Chr13:73693203-73718861 (+)
BALB/cJ MGP_BALBcJ_G0020701
 protein coding gene Chr13:71939910-71962713 (+)
C3H/HeJ MGP_C3HHeJ_G0020495
 protein coding gene Chr13:73371069-73399416 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021138
 protein coding gene Chr13:76559082-76584541 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018705
 protein coding gene Chr13:68266860-68288450 (+)
CAST/EiJ MGP_CASTEiJ_G0020012
 protein coding gene Chr13:72449564-72472870 (+)
CBA/J MGP_CBAJ_G0020454
 protein coding gene Chr13:79402104-79430377 (+)
DBA/2J MGP_DBA2J_G0020579
 protein coding gene Chr13:71270246-71292563 (+)
FVB/NJ MGP_FVBNJ_G0020559
 protein coding gene Chr13:70290173-70313006 (+)
LP/J MGP_LPJ_G0020652
 protein coding gene Chr13:74331339-74357912 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020587
 protein coding gene Chr13:77834403-77858531 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021177
 protein coding gene Chr13:73002410-73028060 (+)
PWK/PhJ MGP_PWKPhJ_G0019766
 protein coding gene Chr13:70003841-70026493 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019589
 protein coding gene Chr13:69458750-69486958 (+)
WSB/EiJ MGP_WSBEiJ_G0020070
 protein coding gene Chr13:73546099-73573858 (+)



Homology
more
  • Human Ortholog
    TERT, telomerase reverse transcriptase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TERT, telomerase reverse transcriptase
  • Synonyms
    CMM9, DKCA2, DKCB4, EST2, hEST2, hTRT, PFBMFT1, TCS1, TP2, TRT
  • Links
    NCBI Gene ID: 7015
    neXtProt AC: NX_O14746
    UniProt: O14746

  • Chr Location
    5p15.33; chr5:1253147-1295068 (-)  GRCh38
Human Diseases
more
  • Diseases
    17 with human TERT associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 8 alleles in 9 genetic backgrounds
    32 phenotypes from multigenic genotypes
    1 images
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In spite of impaired telomerase function, homozygous mutant mice are overtly normal in early generations. Impaired fertility has been reported in later generations for homozygotes of at least one knockout allele.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    119
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    911
  • Tissues
    102
  • cDNA Data
    25
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21752 NCBI Gene Model | MGI Sequence Detail 22933 C57BL/6J ±  kb
    transcript NM_009354 RefSeq | MGI Sequence Detail 4335 ZRU/MplStud  
    polypeptide O70372 UniProt | EBI | MGI Sequence Detail 1122 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 26
      Primer pair 7

      Microarray probesets 4
    References
    more
    • Summaries
      All 205
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 17
      Phenotypes 98
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:352312 Xu X, et al., An association between elevated telomerase reverse transcriptase expression and the immune tolerance disruption of dendritic cells. Cell Commun Signal. 2024 May 23;22(1):284
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory