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Tcf21 Gene Detail
Summary
  • Symbol
    Tcf21
  • Name
    transcription factor 21
  • Synonyms
    bHLHa23, capsulin, epc, epicardin, Pod-1, Pod1, podocyte-expressed 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202715
    NCBI Gene: 21412
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:22693162-22696042 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 10.33 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202715
 protein coding gene Chr10:22693162-22696073 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017070
 protein coding gene Chr10:20739087-20741929 (-)
A/J MGP_AJ_G0017048
 protein coding gene Chr10:20116228-20119063 (-)
AKR/J MGP_AKRJ_G0017010
 protein coding gene Chr10:20440903-20443750 (-)
BALB/cJ MGP_BALBcJ_G0017010
 protein coding gene Chr10:20196369-20199326 (-)
C3H/HeJ MGP_C3HHeJ_G0016830
 protein coding gene Chr10:20668135-20670982 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017468
 protein coding gene Chr10:21322620-21325466 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015169
 protein coding gene Chr10:18905411-18908278 (-)
CAST/EiJ MGP_CASTEiJ_G0016411
 protein coding gene Chr10:20534072-20536894 (-)
CBA/J MGP_CBAJ_G0016803
 protein coding gene Chr10:22292534-22295381 (-)
DBA/2J MGP_DBA2J_G0016909
 protein coding gene Chr10:19862113-19864961 (-)
FVB/NJ MGP_FVBNJ_G0016905
 protein coding gene Chr10:19599648-19602495 (-)
LP/J MGP_LPJ_G0016985
 protein coding gene Chr10:20685907-20688749 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016935
 protein coding gene Chr10:22460517-22464325 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017503
 protein coding gene Chr10:20298028-20300873 (-)
PWK/PhJ MGP_PWKPhJ_G0016196
 protein coding gene Chr10:19612759-19617581 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015977
 protein coding gene Chr10:20095937-20100297 (-)
WSB/EiJ MGP_WSBEiJ_G0016474
 protein coding gene Chr10:20408566-20412399 (-)



Homology
more
  • Human Ortholog
    TCF21, transcription factor 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF21, transcription factor 21
  • Synonyms
    bHLHa23, POD1
  • Links
    NCBI Gene ID: 6943
    neXtProt AC: NX_O43680
    UniProt: O43680

  • Chr Location
    6q23.2; chr6:133889113-133895553 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TCF21 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    81 phenotypes from 6 alleles in 5 genetic backgrounds
    24 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit hypoplastic lungs and kidneys with abnormal vasculature of these organs and the hemopericardium, and die at birth due to respiratory failure. Homozygotes for some mutations are also asplenic. Some alleles cause sex reversal in XY mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1373
  • Tissues
    378
  • cDNA Data
    35
  • Literature Summary
    90
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21412 NCBI Gene Model | MGI Sequence Detail 2881 C57BL/6J ±  kb
    transcript NM_011545 RefSeq | MGI Sequence Detail 1254 ZRU/MplStud  
    polypeptide O35437 UniProt | EBI | MGI Sequence Detail 179 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 1
      cDNA 37
      Primer pair 7
      Other 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 172
      Developmental Gene Expression 90
      Gene Ontology 17
      Phenotypes 64
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:358844 Argiro L, et al., Gastruloids are competent to specify both cardiac and skeletal muscle lineages. Nat Commun. 2024 Nov 23;15(1):10172
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory