Csrp2 MGI Mouse Gene Detail - MGI:1202907 - cysteine and glycine-rich protein 2

Symbol

Csrp2
Name

cysteine and glycine-rich protein 2
Synonyms

Crp2, SmLim

Feature Type

protein coding gene
IDs

MGI:1202907
NCBI Gene: 13008
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:110756037-110775375 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 57.84 cM
Mapping Data

3 experiments

SNPs within 2kb

687 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1202907	protein coding gene	Chr10:110755650-110775483 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017717	protein coding gene	Chr10:113284719-113305593 (+)
A/J	MGP_AJ_G0017694	protein coding gene	Chr10:108990439-109009745 (+)
AKR/J	MGP_AKRJ_G0017656	protein coding gene	Chr10:112172488-112191950 (+)
BALB/cJ	MGP_BALBcJ_G0017658	protein coding gene	Chr10:109392381-109411533 (+)
C3H/HeJ	MGP_C3HHeJ_G0017483	protein coding gene	Chr10:112308543-112328829 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018115	protein coding gene	Chr10:117213300-117234143 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015794	protein coding gene	Chr10:103865295-103884895 (+)
CAST/EiJ	MGP_CASTEiJ_G0017044	protein coding gene	Chr10:112469017-112493909 (+)
CBA/J	MGP_CBAJ_G0017452	protein coding gene	Chr10:121782482-121804461 (+)
DBA/2J	MGP_DBA2J_G0017557	protein coding gene	Chr10:108121157-108140744 (+)
FVB/NJ	MGP_FVBNJ_G0017551	protein coding gene	Chr10:107126988-107146260 (+)
LP/J	MGP_LPJ_G0017631	protein coding gene	Chr10:113919339-113939995 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017580	protein coding gene	Chr10:124499135-124520369 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018153	protein coding gene	Chr10:112182188-112201552 (+)
PWK/PhJ	MGP_PWKPhJ_G0016826	protein coding gene	Chr10:108211529-108231793 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016616	protein coding gene	Chr10:110951688-110972895 (+)
WSB/EiJ	MGP_WSBEiJ_G0017104	protein coding gene	Chr10:112325673-112344978 (+)

Human Ortholog

CSRP2, cysteine and glycine rich protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSRP2, cysteine and glycine rich protein 2
Synonyms

CRP2, LMO5, SmLIM
Links

HGNC:2470

NCBI Gene ID: 1466

neXtProt AC: NX_Q16527

UniProt: Q16527
Chr Location

12q21.2; chr12:76858709-76879023 (-) GRCh38

MGI Vertebrate Homology

Csrp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CSRP2
Gene Tree

Csrp2

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Phenotype Summary

4 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

211
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

205
Targeted

3
Genomic Mutations

1 involving Csrp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

95 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one null allele display increased neointima formation following arterial injury and increased migration of vascular smooth muscle cells in response to PDGF-BB.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

911
Tissues

112
cDNA Data

86
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CSRP2

Xenbase csrp2

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All Sequences

54
RefSeq

2
UniProt

8
CCDS

CCDS24165.1

Ensembl

ENSMUSG00000020186 (Evidence)
NCBI Gene

13008

			Length	Strain/Species	Flank
genomic	13008	NCBI Gene Model \| MGI Sequence Detail	19339	C57BL/6J	± kb
transcript	NM_007792	RefSeq \| MGI Sequence Detail	889	C57BL/6
polypeptide	P97314	UniProt \| EBI \| MGI Sequence Detail	193	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005959 cysteine and glycine-rich protein 2

(term hierarchy)
InterPro Domains

IPR001781 Zinc finger, LIM-type
GlyGen

P97314 1 site, 1 O-linked glycan (1 site)

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All nucleic 90

Genomic 1

cDNA 88

Primer pair 1

Microarray probesets 3

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MGI:2143863

Summaries

All 60

Developmental Gene Expression 13

Gene Ontology 4

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:346522 Li Y, et al., TGF-beta signaling promotes desmoid tumor formation via CSRP2 upregulation. Cancer Sci. 2024 Feb;115(2):401-411

TSS for Csrp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95689	Chr10:110756031-110756049 (+)	3 bp
Tssr95690	Chr10:110767852-110767866 (+)	11,822 bp
Tssr95691	Chr10:110769745-110769746 (+)	13,709 bp
Tssr95692	Chr10:110770152-110770157 (+)	14,118 bp
Tssr95693	Chr10:110773658-110773691 (+)	17,638 bp
Tssr95694	Chr10:110773777-110773790 (+)	17,747 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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