Rrp1 MGI Mouse Gene Detail - MGI:1203500 - ribosomal RNA processing 1

Symbol

Rrp1
Name

ribosomal RNA processing 1
Synonyms

Nnp1, NNP-1

Feature Type

protein coding gene
IDs

MGI:1203500
NCBI Gene: 18114
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:78236218-78248877 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

5 experiments

SNPs within 2kb

414 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1203500	protein coding gene	Chr10:78236196-78248877 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017421	protein coding gene	Chr10:78842751-78856751 (-)
A/J	MGP_AJ_G0017399	protein coding gene	Chr10:76104232-76116880 (-)
AKR/J	MGP_AKRJ_G0017362	protein coding gene	Chr10:78138727-78151374 (-)
BALB/cJ	MGP_BALBcJ_G0017361	protein coding gene	Chr10:76267026-76279668 (-)
C3H/HeJ	MGP_C3HHeJ_G0017184	protein coding gene	Chr10:78252481-78265127 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017817	protein coding gene	Chr10:81628014-81641060 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015508	protein coding gene	Chr10:72451623-72463938 (-)
CAST/EiJ	MGP_CASTEiJ_G0016754	protein coding gene	Chr10:78554303-78568180 (-)
CBA/J	MGP_CBAJ_G0017156	protein coding gene	Chr10:84738348-84753933 (-)
DBA/2J	MGP_DBA2J_G0017264	protein coding gene	Chr10:75344123-75356736 (-)
FVB/NJ	MGP_FVBNJ_G0017256	protein coding gene	Chr10:74523509-74536649 (-)
LP/J	MGP_LPJ_G0017335	protein coding gene	Chr10:79290382-79307898 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017283	protein coding gene	Chr10:86720594-86733245 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017859	protein coding gene	Chr10:78189395-78202023 (-)
PWK/PhJ	MGP_PWKPhJ_G0016536	protein coding gene	Chr10:75226881-75239820 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016321	protein coding gene	Chr10:77394723-77407266 (-)
WSB/EiJ	MGP_WSBEiJ_G0016814	protein coding gene	Chr10:78180731-78194496 (-)

Human Ortholog

RRP1, ribosomal RNA processing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RRP1, ribosomal RNA processing 1
Synonyms

D21S2056E, NNP-1, NOP52, RRP1A
Links

HGNC:18785

NCBI Gene ID: 8568

neXtProt AC: NX_P56182

UniProt: P56182
Chr Location

21q22.3; chr21:43789513-43805293 (+) GRCh38

MGI Vertebrate Homology

Rrp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RRP1
Gene Tree

Rrp1

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References

2 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

5
Genomic Mutations

4 involving Rrp1
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

774
Tissues

66
cDNA Data

214
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

62
RefSeq

6
UniProt

4
CCDS

CCDS35961.1

Ensembl

ENSMUSG00000061032 (Evidence)
NCBI Gene

18114

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061032	Ensembl Gene Model \| MGI Sequence Detail	12660	C57BL/6J	± kb
transcript	ENSMUST00000062678	Ensembl \| MGI Sequence Detail	1984	Not Applicable
polypeptide	ENSMUSP00000058785	Ensembl \| MGI Sequence Detail	494	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014309 ribosomal RNA processing protein 1 homolog A

(term hierarchy)
InterPro Domains

IPR010301 Ribosomal RNA processing protein 1

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All nucleic 225

Genomic 9

cDNA 214

Primer pair 1

Other 1

Microarray probesets 6

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MGI:2143715, MGI:2143716, MGI:2143730

Summaries

All 67

Developmental Gene Expression 3

Diseases 2

Gene Ontology 6

Phenotypes 36
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Rrp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98303	Chr10:78248783-78248855 (-)	58 bp
Tssr3266	Chr10:78248754-78248761 (-)	119 bp
Tssr98302	Chr10:78248685-78248696 (-)	186 bp
Tssr98301	Chr10:78240945-78240955 (-)	7,927 bp
Tssr98300	Chr10:78238909-78238916 (-)	9,964 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24