Birc5 MGI Mouse Gene Detail - MGI:1203517 - baculoviral IAP repeat-containing 5

Symbol

Birc5
Name

baculoviral IAP repeat-containing 5
Synonyms

Api4, survivin, TIAP

Feature Type

protein coding gene
IDs

MGI:1203517
NCBI Gene: 11799
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:117740077-117746569 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 82.96 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

275 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1203517	protein coding gene	Chr11:117740063-117746569 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019456	protein coding gene	Chr11:122133369-122140724 (+)
A/J	MGP_AJ_G0019424	protein coding gene	Chr11:116721794-116729604 (+)
AKR/J	MGP_AKRJ_G0019394	protein coding gene	Chr11:120275520-120282014 (+)
BALB/cJ	MGP_BALBcJ_G0019399	protein coding gene	Chr11:117092389-117098872 (+)
C3H/HeJ	MGP_C3HHeJ_G0019205	protein coding gene	Chr11:120559564-120568256 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019848	protein coding gene	Chr11:125859166-125865706 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017473	protein coding gene	Chr11:113729491-113734791 (+)
CAST/EiJ	MGP_CASTEiJ_G0018759	protein coding gene	Chr11:121982465-121988883 (+)
CBA/J	MGP_CBAJ_G0019176	protein coding gene	Chr11:130815114-130821592 (+)
DBA/2J	MGP_DBA2J_G0019288	protein coding gene	Chr11:116122196-116128732 (+)
FVB/NJ	MGP_FVBNJ_G0019280	protein coding gene	Chr11:115741374-115748643 (+)
LP/J	MGP_LPJ_G0019358	protein coding gene	Chr11:122457370-122465034 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019313	protein coding gene	Chr11:129773324-129780647 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019887	protein coding gene	Chr11:120926299-120932788 (+)
PWK/PhJ	MGP_PWKPhJ_G0018525	protein coding gene	Chr11:117479519-117486855 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018317	protein coding gene	Chr11:120655128-120661372 (+)
WSB/EiJ	MGP_WSBEiJ_G0018811	protein coding gene	Chr11:120889964-120896459 (+)

Human Ortholog

BIRC5, baculoviral IAP repeat containing 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BIRC5, baculoviral IAP repeat containing 5
Synonyms

API4, EPR-1
Links

HGNC:593

NCBI Gene ID: 332

neXtProt AC: NX_O15392

UniProt: O15392
Chr Location

17q25.3; chr17:78214186-78225636 (+) GRCh38

MGI Vertebrate Homology

Birc5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BIRC5
Gene Tree

Birc5

Diseases

2 with human BIRC5 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				transitional cell carcinoma IDs transitional cell carcinoma DOID:2671 DOID:3995 MESH:D002295 NCI:C2930 NCI:C6783 UMLS_CUI:C0007138 UMLS_CUI:C0334265

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

32 phenotypes from 6 alleles in 6 genetic backgrounds
10 phenotypes from multigenic genotypes
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

5
Gene trapped

7
Targeted

6
Transgenic

6
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants die during early embryonic development.

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All GO Annotations

102
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

976
Tissues

201
cDNA Data

95
Literature Summary

69

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase birc5, birc5l

ZFIN birc5a, birc5b

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All Sequences

44
RefSeq

4
UniProt

2
CCDS

CCDS25694.1, CCDS25695.1

Ensembl

ENSMUSG00000017716 (Evidence)
NCBI Gene

11799

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017716	Ensembl Gene Model \| MGI Sequence Detail	6493	C57BL/6J	± kb
transcript	ENSMUST00000081387	Ensembl \| MGI Sequence Detail	947	Not Applicable
polypeptide	ENSMUSP00000079124	Ensembl \| MGI Sequence Detail	140	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004753 baculoviral IAP repeat-containing protein 5

(term hierarchy)
PDB

1M4M
InterPro Domains

IPR051190 Baculoviral IAP repeat-containing

IPR001370 BIR repeat

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All nucleic 103

Genomic 1

cDNA 98

Primer pair 4

Microarray probesets 3

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MGI:1196343

Summaries

All 183

Developmental Gene Expression 69

Gene Ontology 15

Phenotypes 48
Earliest

J:42738 Tewari M, et al., AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res. 1997 Sep 15;57(18):4063-9
Latest

J:358134 Soma S, et al., O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. Stem Cells. 2024 Jan 13;42(1):55-63

TSS for Birc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106094	Chr11:117740049-117740060 (+)	-22 bp
Tssr106095	Chr11:117740099-117740108 (+)	27 bp
Tssr106096	Chr11:117740112-117740166 (+)	62 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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