Prl4a1 MGI Mouse Gene Detail - MGI:1206587 - prolactin family 4, subfamily a, member 1

Symbol

Prl4a1
Name

prolactin family 4, subfamily a, member 1
Synonyms

PLP-A, Prlpa

Feature Type

protein coding gene
IDs

MGI:1206587
NCBI Gene: 19110
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:28200195-28207531 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 12.66 cM
Mapping Data

2 experiments

SNPs within 2kb

282 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1206587	protein coding gene	Chr13:28200195-28207542 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020407	protein coding gene	Chr13:25741029-25748365 (+)
A/J	MGP_AJ_G0020362	protein coding gene	Chr13:25207746-25215082 (+)
AKR/J	MGP_AKRJ_G0020339	protein coding gene	Chr13:25631339-25638675 (+)
BALB/cJ	MGP_BALBcJ_G0020357	protein coding gene	Chr13:25235419-25242755 (+)
C3H/HeJ	MGP_C3HHeJ_G0020160	protein coding gene	Chr13:25712836-25720172 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020793	protein coding gene	Chr13:26680260-26687704 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018384	protein coding gene	Chr13:23613645-23619674 (+)
CAST/EiJ	MGP_CASTEiJ_G0019677	protein coding gene	Chr13:25321291-25328497 (+)
CBA/J	MGP_CBAJ_G0020116	protein coding gene	Chr13:27819080-27826376 (+)
DBA/2J	MGP_DBA2J_G0020238	protein coding gene	Chr13:24691953-24699289 (+)
FVB/NJ	MGP_FVBNJ_G0020223	protein coding gene	Chr13:24285842-24293178 (+)
LP/J	MGP_LPJ_G0020315	protein coding gene	Chr13:26060491-26067827 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020250	protein coding gene	Chr13:28049737-28059616 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020834	protein coding gene	Chr13:25367403-25374739 (+)
PWK/PhJ	MGP_PWKPhJ_G0019432	protein coding gene	Chr13:24815670-24823106 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019252	protein coding gene	Chr13:24089862-24097201 (+)
WSB/EiJ	MGP_WSBEiJ_G0019739	protein coding gene	Chr13:25581292-25588633 (+)

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MGI Vertebrate Homology

Prl4a1 stringent orthology
1 mouse;1 rat
Gene Tree

Prl4a1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Prl4a1
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female mice homozygous for a knock-out allele are unable to adapt to hypobaric hypoxia during gestation, resulting in pregnancy failure.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

764
Tissues

22
cDNA Data

55
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS26409.1

Ensembl

ENSMUSG00000005891 (Evidence)
NCBI Gene

19110

			Length	Strain/Species	Flank
genomic	19110	NCBI Gene Model \| MGI Sequence Detail	7337	C57BL/6J	± kb
transcript	NM_011165	RefSeq \| MGI Sequence Detail	865	ZRU/MplStud
polypeptide	O35256	UniProt \| EBI \| MGI Sequence Detail	227	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013544 prolactin-4A1

(term hierarchy)
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR018116 Somatotropin hormone, conserved site

IPR001400 Somatotropin/prolactin
GlyGen

O35256 1 site

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All nucleic 57

Genomic 1

cDNA 56

Microarray probesets 3

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MGI:2145153

Summaries

All 50

Developmental Gene Expression 11

Gene Ontology 7

Phenotypes 14
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:330449 Rusidze M, et al., Loss of function of the maternal membrane oestrogen receptor ERalpha alters expansion of trophoblast cells and impacts mouse fertility. Development. 2022 Oct 1;149(19):dev200683

TSS for Prl4a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119048	Chr13:28200193-28200198 (+)	1 bp
Tssr119049	Chr13:28204226-28204235 (+)	4,036 bp
Tssr119050	Chr13:28205397-28205403 (+)	5,205 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24