Naga MGI Mouse Gene Detail - MGI:1261422 - N-acetyl galactosaminidase, alpha

Symbol

Naga
Name

N-acetyl galactosaminidase, alpha

Feature Type

protein coding gene
IDs

MGI:1261422
NCBI Gene: 17939
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:82213746-82222983 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.56 cM, cytoband E
Mapping Data

3 experiments

SNPs within 2kb

360 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261422	protein coding gene	Chr15:82213733-82223126 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022142	protein coding gene	Chr15:82843020-82853465 (-)
A/J	MGP_AJ_G0022102	protein coding gene	Chr15:79903607-79914072 (-)
AKR/J	MGP_AKRJ_G0022078	protein coding gene	Chr15:82124503-82134775 (-)
BALB/cJ	MGP_BALBcJ_G0022108	protein coding gene	Chr15:79951825-79963985 (-)
C3H/HeJ	MGP_C3HHeJ_G0021879	protein coding gene	Chr15:82145777-82157132 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022551	protein coding gene	Chr15:86082668-86093186 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020080	protein coding gene	Chr15:76336435-76345610 (-)
CAST/EiJ	MGP_CASTEiJ_G0021399	protein coding gene	Chr15:82932664-82943392 (-)
CBA/J	MGP_CBAJ_G0021844	protein coding gene	Chr15:88790081-88802605 (-)
DBA/2J	MGP_DBA2J_G0021972	protein coding gene	Chr15:79371970-79381438 (-)
FVB/NJ	MGP_FVBNJ_G0021949	protein coding gene	Chr15:78442911-78452257 (-)
LP/J	MGP_LPJ_G0022041	protein coding gene	Chr15:82991926-83002424 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021970	protein coding gene	Chr15:93673101-93685397 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022565	protein coding gene	Chr15:82237297-82246485 (-)
PWK/PhJ	MGP_PWKPhJ_G0021141	protein coding gene	Chr15:79431010-79441491 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020980	protein coding gene	Chr15:82012359-82021408 (-)
WSB/EiJ	MGP_WSBEiJ_G0021450	protein coding gene	Chr15:82657346-82667943 (-)

Human Ortholog

NAGA, alpha-N-acetylgalactosaminidase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAGA, alpha-N-acetylgalactosaminidase
Synonyms

D22S674, GALB
Links

HGNC:7631

NCBI Gene ID: 4668

neXtProt AC: NX_P17050

UniProt: P17050
Chr Location

22q13.2; chr22:42058334-42070842 (-) GRCh38

MGI Vertebrate Homology

Naga stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NAGA
Gene Tree

Naga

Diseases

4 with human NAGA associations

				Human Disease	Mouse Models
				angiokeratoma IDs angiokeratoma DOID:479 DOID:665 MESH:D000794 NCI:C2874 NCI:C4488 UMLS_CUI:C0002985 UMLS_CUI:C0346075
				Kanzaki disease IDs Kanzaki disease DOID:0112319 OMIM:609242 ORDO:79280
				neuroaxonal dystrophy IDs neuroaxonal dystrophy DOID:2367 MESH:D019150 NCI:C161542 UMLS_CUI:C0338473
				Schindler disease type 1 IDs Schindler disease type 1 DOID:0112318 OMIM:609241 ORDO:79279

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

2
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving Naga
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

889
Tissues

104
cDNA Data

82
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase naga

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All Sequences

68
RefSeq

9
UniProt

9
CCDS

CCDS27686.1

Ensembl

ENSMUSG00000022453 (Evidence)
NCBI Gene

17939

			Length	Strain/Species	Flank
genomic	17939	NCBI Gene Model \| MGI Sequence Detail	9238	C57BL/6J	± kb
transcript	NM_008669	RefSeq \| MGI Sequence Detail	1856	ZRU/MplStud
polypeptide	Q9QWR8	UniProt \| EBI \| MGI Sequence Detail	415	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000010959 alpha-N-acetylgalactosaminidase

(term hierarchy)
EC

3.2.1.-, 3.2.1.49
InterPro Domains

IPR013785 Aldolase-type TIM barrel

IPR035373 Alpha galactosidase A, C-terminal beta-sandwich domain

IPR002241 Glycoside hydrolase, family 27

IPR000111 Glycoside hydrolase family 27/36, conserved site

IPR017853 Glycoside hydrolase superfamily

IPR013780 Glycosyl hydrolase, all-beta
GlyGen

Q9QWR8 4 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 96

Genomic 13

cDNA 82

Primer pair 1

Microarray probesets 3

Summaries

All 57

Developmental Gene Expression 3

Diseases 1

Gene Ontology 6

Phenotypes 28
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Naga:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4669	Chr15:82223065-82223076 (-)	-88 bp
Tssr135545	Chr15:82223058-82223065 (-)	-79 bp
Tssr135544	Chr15:82223002-82223055 (-)	-46 bp
Tssr135543	Chr15:82222971-82222992 (-)	1 bp
Tssr135542	Chr15:82221210-82221221 (-)	1,767 bp
Tssr135541	Chr15:82216648-82216673 (-)	6,322 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24