Endog MGI Mouse Gene Detail - MGI:1261433

Symbol

Endog
Name

endonuclease G

Feature Type

protein coding gene
IDs

MGI:1261433
NCBI Gene: 13804
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:30061525-30064057 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.29 cM, cytoband B
Mapping Data

1 experiment

SNPs within 2kb

194 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261433	protein coding gene	Chr2:30061505-30064081 (+)
129S1/SvImJ	ENSMUSG00200051547	protein coding gene	Chr2:27031987-27034563 (+)
A/J	ENSMUSG00195039083	protein coding gene	Chr2:27125358-27127934 (+)
AKR/J	ENSMUSG00220048441	protein coding gene	Chr2:27243902-27246478 (+)
BALB/cJ	ENSMUSG00180052994	protein coding gene	Chr2:27144882-27147458 (+)
C3H/HeJ	ENSMUSG00175053169	protein coding gene	Chr2:27114197-27116773 (+)
C57BL/6NJ	ENSMUSG00215048582	protein coding gene	Chr2:27179623-27182199 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023383	protein coding gene	Chr2:26048426-26050956 (+)
CAST/EiJ	ENSTCUG00005052229	protein coding gene	Chr2:26853852-26856445 (+)
CBA/J	ENSMUSG00210016773	protein coding gene	Chr2:27187125-27189704 (+)
DBA/2J	ENSMUSG00185049345	protein coding gene	Chr2:27039416-27041992 (+)
FVB/NJ	ENSMUSG00205046696	protein coding gene	Chr2:26891481-26894057 (+)
JF1/MsJ	ENSUMUG00000035217	protein coding gene	Chr2:26938553-26941114 (+)
LP/J	ENSMUSG00230043533	protein coding gene	Chr2:28967708-28970284 (+)
NOD/ShiLtJ	ENSMUSG00190045246	protein coding gene	Chr2:27146158-27148734 (+)
NZO/HlLtJ	ENSMUSG00225007912	protein coding gene	Chr2:36717308-36719884 (+)
PWK/PhJ	ENSLUMG00010049979	protein coding gene	Chr2:27015848-27018417 (+)
SPRET/EiJ	ENSMSPG00010040398	protein coding gene	Chr2:27739991-27742528 (+)
WSB/EiJ	ENSIUOG00005052303	protein coding gene	Chr2:26999098-27001704 (+)

Human Ortholog

ENDOG, endonuclease G

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ENDOG, endonuclease G
Links

HGNC:3346

NCBI Gene ID: 2021

UniProt: Q14249
Chr Location

9q34.11; chr9:128818461-128822676 (+) GRCh38

MGI Vertebrate Homology

Endog stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ENDOG
Gene Tree

Endog

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Phenotype Summary

8 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

5
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and have no detectable abnormalities.

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All GO Annotations

66
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

660
Tissues

23
cDNA Data

8
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase endog

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All Sequences

36
RefSeq

5
UniProt

2
CCDS

CCDS15872.1

Ensembl

ENSMUSG00000015337 (Evidence)
NCBI Gene

13804

			Length	Strain/Species	Flank
genomic	13804	NCBI Gene Model \| MGI Sequence Detail	2533	C57BL/6J	± kb
transcript	NR_184725	RefSeq \| MGI Sequence Detail	1403	C57BL/6
polypeptide	O08600	UniProt \| EBI \| MGI Sequence Detail	294	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007076 endonuclease G, mitochondrial

(term hierarchy)
PDB

6LYF, 6M3F, 6M3T, 6M3U, 6NJT, 6NJU
EC

3.1.30.-
InterPro Domains

IPR018524 DNA/RNA non-specific endonuclease, active site

IPR001604 DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain

IPR044929 DNA/RNA non-specific endonuclease superfamily

IPR020821 ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain

IPR044925 His-Me finger superfamily

IPR040255 Non-specific endonuclease

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All nucleic 15

Genomic 6

cDNA 8

Primer pair 1

Antibodies 1

Microarray probesets 4

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 16

Phenotypes 20
Earliest

J:43924 Prats E, et al., Characterization and expression of the mouse endonuclease G gene. DNA Cell Biol. 1997 Sep;16(9):1111-22
Latest

J:351285 Zhu C, et al., Caspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation. Cell Death Dis. 2024 Jul 9;15(7):486

TSS for Endog:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17091	Chr2:30061498-30061509 (+)	-21 bp
Tssr17092	Chr2:30061514-30061532 (+)	-2 bp
Tssr17093	Chr2:30061541-30061548 (+)	20 bp
Tssr17094	Chr2:30061555-30061566 (+)	36 bp
Tssr17095	Chr2:30061569-30061576 (+)	48 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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