Olr1 MGI Mouse Gene Detail - MGI:1261434 - oxidized low density lipoprotein (lectin-like) receptor 1

Symbol

Olr1
Name

oxidized low density lipoprotein (lectin-like) receptor 1
Synonyms

LOX-1, Scare1, SR-EI

Feature Type

protein coding gene
IDs

MGI:1261434
NCBI Gene: 108078
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:129462207-129484128 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 63.35 cM
Mapping Data

2 experiments

SNPs within 2kb

789 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261434	protein coding gene	Chr6:129456113-129484312 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031349	protein coding gene	Chr6:133152888-133175704 (-)
A/J	MGP_AJ_G0031320	protein coding gene	Chr6:128059723-128081936 (-)
AKR/J	MGP_AKRJ_G0031248	protein coding gene	Chr6:131555442-131577465 (-)
BALB/cJ	MGP_BALBcJ_G0031327	protein coding gene	Chr6:127703786-127725772 (-)
C3H/HeJ	MGP_C3HHeJ_G0031051	protein coding gene	Chr6:131753238-131775295 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031786	protein coding gene	Chr6:136652112-136674021 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028932	protein coding gene	Chr6:126380404-126402433 (-)
CAST/EiJ	MGP_CASTEiJ_G0030429	protein coding gene	Chr6:131982964-132006113 (-)
CBA/J	MGP_CBAJ_G0031011	protein coding gene	Chr6:142029466-142057742 (-)
DBA/2J	MGP_DBA2J_G0031168	protein coding gene	Chr6:127015808-127038233 (-)
FVB/NJ	MGP_FVBNJ_G0031118	protein coding gene	Chr6:125895879-125919940 (-)
LP/J	MGP_LPJ_G0031248	protein coding gene	Chr6:133368941-133395770 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031156	protein coding gene	Chr6:145883710-145906888 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031819	protein coding gene	Chr6:131627474-131650113 (-)
PWK/PhJ	MGP_PWKPhJ_G0030147	protein coding gene	Chr6:125293486-125316388 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029976	protein coding gene	Chr6:129640876-129667718 (-)
WSB/EiJ	MGP_WSBEiJ_G0030517	protein coding gene	Chr6:132053455-132076113 (-)

Human Ortholog

OLR1, oxidized low density lipoprotein receptor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OLR1, oxidized low density lipoprotein receptor 1
Synonyms

CLEC8A, LOX1, LOXIN, SCARE1, SLOX1
Links

HGNC:8133

NCBI Gene ID: 4973

neXtProt AC: NX_P78380

UniProt: P78380
Chr Location

12p13.2; chr12:10158301-10176266 (-) GRCh38

MGI Vertebrate Homology

Olr1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: OLR1
Gene Tree

Olr1

Diseases

3 with human OLR1 associations

				Human Disease	Mouse Models
				cerebral amyloid angiopathy IDs cerebral amyloid angiopathy DOID:9246 MESH:D028243 ORDO:85458 UMLS_CUI:C0268393 UMLS_CUI:C1510489 UMLS_CUI:C1527338 UMLS_CUI:C1956349
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

6
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in no obvious phenotype.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

37
cDNA Data

12
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

54
RefSeq

11
UniProt

5
CCDS

CCDS20588.1, CCDS80619.1, CCDS80620.1

Ensembl

ENSMUSG00000030162 (Evidence)
NCBI Gene

108078

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030162	Ensembl Gene Model \| MGI Sequence Detail	21922	C57BL/6J	± kb
transcript	ENSMUST00000032265	Ensembl \| MGI Sequence Detail	3572	Not Applicable
polypeptide	ENSMUSP00000032265	Ensembl \| MGI Sequence Detail	363	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011634 oxidized low-density lipoprotein receptor 1

(term hierarchy)
InterPro Domains

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR033992 Natural killer cell receptor-like, C-type lectin-like domain

IPR052332 Oxidized LDL receptor 1-like
GlyGen

Q9EQ09 2 sites

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All nucleic 21

Genomic 2

cDNA 12

Primer pair 5

Other 2

Microarray probesets 3

Summaries

All 79

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 32
Earliest

J:47339 Hoshikawa H, et al., High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1). Biochem Biophys Res Commun. 1998 Apr 28;245(3):841-6
Latest

J:339300 Zhang Q, et al., Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15. Biochim Biophys Acta Mol Basis Dis. 2023 Jul 17;1869(8):166805

TSS for Olr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63653	Chr6:129484140-129484144 (-)	-14 bp
Tssr63652	Chr6:129484119-129484134 (-)	1 bp
Tssr63651	Chr6:129471371-129471385 (-)	12,750 bp
Tssr63650	Chr6:129464749-129464759 (-)	19,374 bp
Tssr63649	Chr6:129463965-129463975 (-)	20,158 bp
Tssr63648	Chr6:129463925-129463939 (-)	20,196 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24