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Dnmt3b Gene Detail
Summary
  • Symbol
    Dnmt3b
  • Name
    DNA methyltransferase 3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261819
    NCBI Gene: 13436
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:153491370-153529650 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.79 cM, cytoband A2-A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1027 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261819
 protein coding gene Chr2:153491332-153529650 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026696
 protein coding gene Chr2:158320056-158365492 (+)
A/J MGP_AJ_G0026662
 protein coding gene Chr2:151969070-152009185 (+)
AKR/J MGP_AKRJ_G0026633
 protein coding gene Chr2:156419413-156458582 (+)
BALB/cJ MGP_BALBcJ_G0026672
 protein coding gene Chr2:152274358-152318137 (+)
C3H/HeJ MGP_C3HHeJ_G0026414
 protein coding gene Chr2:156804138-156848853 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027121
 protein coding gene Chr2:162918189-162941709 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024491
 protein coding gene Chr2:145541539-145580439 (+)
CAST/EiJ MGP_CASTEiJ_G0025875
 protein coding gene Chr2:157066688-157112148 (+)
CBA/J MGP_CBAJ_G0026393
 protein coding gene Chr2:168930835-168980716 (+)
DBA/2J MGP_DBA2J_G0026528
 protein coding gene Chr2:151182406-151233572 (+)
FVB/NJ MGP_FVBNJ_G0026494
 protein coding gene Chr2:149645213-149687279 (+)
LP/J MGP_LPJ_G0026633
 protein coding gene Chr2:158454053-158497310 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026516
 protein coding gene Chr2:172920152-172965109 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027176
 protein coding gene Chr2:156325528-156367644 (+)
PWK/PhJ MGP_PWKPhJ_G0025609
 protein coding gene Chr2:150717041-150757036 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025412
 protein coding gene Chr2:155164769-155209626 (+)
WSB/EiJ MGP_WSBEiJ_G0025945
 protein coding gene Chr2:157214710-157258846 (+)



Homology
more
  • Human Ortholog
    DNMT3B, DNA methyltransferase 3 beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNMT3B, DNA methyltransferase 3 beta
  • Synonyms
    FSHD4, ICF, ICF1, M.HsaIIIB
  • Links
    NCBI Gene ID: 1789
    neXtProt AC: NX_Q9UBC3
    UniProt: Q9UBC3

  • Chr Location
    20q11.21; chr20:32762385-32809359 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dnmt3b mouse models; 12 with human DNMT3B associations

Human Disease Mouse Models
      
IDs
 View 7 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 9 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit growth retardation and rostral neural tube defects, and die prenatally. Mutants exhibit slight under-methylation of endogenous viral DNA and substantial demethylation of minor satellite DNA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1934
  • Tissues
    716
  • cDNA Data
    15
  • Literature Summary
    75
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027478 Ensembl Gene Model | MGI Sequence Detail 38281 C57BL/6J ±  kb
    transcript ENSMUST00000056495 Ensembl | MGI Sequence Detail 4318 Not Applicable  
    polypeptide ENSMUSP00000051830 Ensembl | MGI Sequence Detail 860 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 2
      cDNA 15
      Primer pair 28
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 250
      Developmental Gene Expression 75
      Diseases 2
      Gene Ontology 31
      Phenotypes 92
    • Earliest
      J:48528 Okano M, et al., Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [letter]. Nat Genet. 1998 Jul;19(3):219-20
    • Latest
      J:350368 Yao S, et al., Liver-specific deletion of de novo DNA methyltransferases protects against glucose intolerance in high-fat diet-fed male mice. FASEB J. 2024 May 31;38(10):e23690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory