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Vps37a Gene Detail
Summary
  • Symbol
    Vps37a
  • Name
    vacuolar protein sorting 37A
  • Synonyms
    2210018P21Rik, 4930592A21Rik, D8Ertd531e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261835
    NCBI Gene: 52348
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:40964824-41003798 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.89 cM, cytoband B1.2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    953 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261835
 protein coding gene Chr8:40964482-41004175 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033554
 protein coding gene Chr8:39314305-39355467 (+)
A/J MGP_AJ_G0033534
 protein coding gene Chr8:37816473-37855238 (+)
AKR/J MGP_AKRJ_G0033458
 protein coding gene Chr8:38934222-38973176 (+)
BALB/cJ MGP_BALBcJ_G0033530
 protein coding gene Chr8:37905819-37949096 (+)
C3H/HeJ MGP_C3HHeJ_G0033242
 protein coding gene Chr8:39327493-39367560 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034046
 protein coding gene Chr8:40840374-40883739 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030995
 protein coding gene Chr8:34461531-34501399 (+)
CAST/EiJ MGP_CASTEiJ_G0032570
 protein coding gene Chr8:38855864-38898232 (+)
CBA/J MGP_CBAJ_G0033220
 protein coding gene Chr8:42499949-42542449 (+)
DBA/2J MGP_DBA2J_G0033373
 protein coding gene Chr8:37668647-37708461 (+)
FVB/NJ MGP_FVBNJ_G0033318
 protein coding gene Chr8:37245826-37285282 (+)
LP/J MGP_LPJ_G0033463
 protein coding gene Chr8:39336066-39376418 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033360
 protein coding gene Chr8:42285942-42327581 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034065
 protein coding gene Chr8:39136360-39176982 (+)
PWK/PhJ MGP_PWKPhJ_G0032279
 protein coding gene Chr8:37214013-37254117 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032111
 protein coding gene Chr8:38337669-38378091 (+)
WSB/EiJ MGP_WSBEiJ_G0032685
 protein coding gene Chr8:39332242-39372001 (+)



Homology
more
  • Human Ortholog
    VPS37A, VPS37A subunit of ESCRT-I
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS37A, VPS37A subunit of ESCRT-I
  • Synonyms
    HCRP1, PQBP2, SPG53
  • Links
    NCBI Gene ID: 137492
    neXtProt AC: NX_Q8NEZ2
    UniProt: Q8NEZ2

  • Chr Location
    8p22; chr8:17246931-17333455 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human VPS37A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    39
  • cDNA Data
    23
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031600 Ensembl Gene Model | MGI Sequence Detail 38975 C57BL/6J ±  kb
    transcript ENSMUST00000098817 Ensembl | MGI Sequence Detail 6002 Not Applicable  
    polypeptide ENSMUSP00000096415 Ensembl | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017335 vacuolar protein sorting-associated protein 37A
      (term hierarchy)
    • InterPro Domains
      IPR037202 ESCRT assembly domain
      IPR029012 Helix hairpin bin domain superfamily
      IPR009851 Modifier of rudimentary, Modr
      IPR016135 Ubiquitin-conjugating enzyme/RWD-like
    • GlyGen
      Q8CHS8 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 25
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1914764, MGI:1923157, MGI:2142784
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory