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Ehf Gene Detail
Summary
  • Symbol
    Ehf
  • Name
    ets homologous factor
  • Synonyms
    9030625L19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270840
    NCBI Gene: 13661
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:103093776-103133620 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 54.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270840
 protein coding gene Chr2:103093776-103133623 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026202
 protein coding gene Chr2:105235475-105275723 (-)
A/J MGP_AJ_G0026163
 protein coding gene Chr2:100891073-100931450 (-)
AKR/J MGP_AKRJ_G0026144
 protein coding gene Chr2:103630479-103670214 (-)
BALB/cJ MGP_BALBcJ_G0026172
 protein coding gene Chr2:101176296-101216485 (-)
C3H/HeJ MGP_C3HHeJ_G0025923
 protein coding gene Chr2:103988104-104027959 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026623
 protein coding gene Chr2:108778929-108818680 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024014
 protein coding gene Chr2:96572171-96611918 (-)
CAST/EiJ MGP_CASTEiJ_G0025388
 protein coding gene Chr2:104445838-104485780 (-)
CBA/J MGP_CBAJ_G0025901
 protein coding gene Chr2:112490376-112530268 (-)
DBA/2J MGP_DBA2J_G0026037
 protein coding gene Chr2:100458899-100498737 (-)
FVB/NJ MGP_FVBNJ_G0026000
 protein coding gene Chr2:99458370-99498461 (-)
LP/J MGP_LPJ_G0026141
 protein coding gene Chr2:105371860-105413142 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026026
 protein coding gene Chr2:116414075-116453855 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026677
 protein coding gene Chr2:103845097-103884837 (-)
PWK/PhJ MGP_PWKPhJ_G0025123
 protein coding gene Chr2:99961253-100002134 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024924
 protein coding gene Chr2:103066559-103107879 (-)
WSB/EiJ MGP_WSBEiJ_G0025455
 protein coding gene Chr2:104550849-104590817 (-)



Homology
more
  • Human Ortholog
    EHF, ETS homologous factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EHF, ETS homologous factor
  • Synonyms
    ESE3, ESE3B, ESEJ
  • Links
    NCBI Gene ID: 26298
    neXtProt AC: NX_Q9NZC4
    UniProt: Q9NZC4

  • Chr Location
    11p13; chr11:34621093-34663288 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced intestinal stem cells with impaired organoid formation capacity and shorter crypts of Lieberkuhn and small intestinal villi.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    126
  • cDNA Data
    107
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13661 NCBI Gene Model | MGI Sequence Detail 39845 C57BL/6J ±  kb
    transcript NM_007914 RefSeq | MGI Sequence Detail 4387 C57BL/6  
    polypeptide O70273 UniProt | EBI | MGI Sequence Detail 300 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 107
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1918797, MGI:2139177
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 18
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:349758 Nightingale R, et al., Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis. Dev Cell. 2024 May 20;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory