Cideb MGI Mouse Gene Detail - MGI:1270844 - cell death-inducing DNA fragmentation factor, alpha subunit-like effector B

Symbol

Cideb
Name

cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
Synonyms

1110030C18Rik, CIDE-B, DFFA-like B

Feature Type

protein coding gene
IDs

MGI:1270844
NCBI Gene: 12684
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:55991509-55995881 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

163 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1270844	protein coding gene	Chr14:55991507-55995915 (-)
129S1/SvImJ	ENSMUSG00200040440	protein coding gene	Chr14:44579220-44583628 (-)
A/J	ENSMUSG00195031262	protein coding gene	Chr14:44795965-44800373 (-)
AKR/J	ENSMUSG00220026940	protein coding gene	Chr14:44123838-44128246 (-)
BALB/cJ	ENSMUSG00180048643	protein coding gene	Chr14:44419667-44424074 (-)
C3H/HeJ	ENSMUSG00175039519	protein coding gene	Chr14:46102008-46106416 (-)
C57BL/6NJ	ENSMUSG00215047678	protein coding gene	Chr14:44314744-44319152 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019316	protein coding gene	Chr14:47177411-47181837 (-)
CAST/EiJ	ENSTCUG00005048217	protein coding gene	Chr14:46099648-46104050 (-)
CBA/J	ENSMUSG00210039490	protein coding gene	Chr14:44782549-44786958 (-)
DBA/2J	ENSMUSG00185053962	protein coding gene	Chr14:49849797-49854207 (-)
FVB/NJ	ENSMUSG00205021892	protein coding gene	Chr14:44193107-44197515 (-)
JF1/MsJ	ENSUMUG00000040004	protein coding gene	Chr14:61083221-61087619 (-)
LP/J	ENSMUSG00230052634	protein coding gene	Chr14:61945081-61949489 (-)
NOD/ShiLtJ	ENSMUSG00190044727	protein coding gene	Chr14:44556493-44560900 (-)
NZO/HlLtJ	ENSMUSG00225045340	protein coding gene	Chr14:52235437-52239845 (-)
PWK/PhJ	ENSLUMG00010043626	protein coding gene	Chr14:44005205-44009613 (-)
SPRET/EiJ	ENSMSPG00010045522	protein coding gene	Chr14:47408175-47412366 (-)
WSB/EiJ	ENSIUOG00005039845	protein coding gene	Chr14:43997691-44002100 (-)

Human Ortholog

CIDEB, cell death inducing DFFA like effector b

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CIDEB, cell death inducing DFFA like effector b
Links

HGNC:1977

NCBI Gene ID: 27141

UniProt: Q9UHD4
Chr Location

14q12; chr14:24305187-24311440 (-) GRCh38

MGI Vertebrate Homology

Cideb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CIDEB
Gene Tree

Cideb

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Cideb
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display a lean phenotype, increased energy expenditure and improved insulin sensitivity and are resistant to high-fat diet-induced obesity, hyperlipidemia, or liver steatosis.

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All GO Annotations

45
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

695
Tissues

93
cDNA Data

74
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cideb

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS27127.1

Ensembl

ENSMUSG00000022219 (Evidence)
NCBI Gene

12684

			Length	Strain/Species	Flank
genomic	12684	NCBI Gene Model \| MGI Sequence Detail	4373	C57BL/6J	± kb
transcript	NM_009894	RefSeq \| MGI Sequence Detail	1186	C57BL/6
polypeptide	O70303	UniProt \| EBI \| MGI Sequence Detail	219	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005493 lipid transferase CIDEB

(term hierarchy)
InterPro Domains

IPR003508 CIDE-N domain

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All nucleic 75

cDNA 74

Primer pair 1

Microarray probesets 3

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MGI:1915915, MGI:2145691

Summaries

All 53

Developmental Gene Expression 5

Gene Ontology 15

Phenotypes 15
Earliest

J:47647 Inohara N, et al., CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998 May 1;17(9):2526-33
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cideb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128884	Chr14:55995920-55995946 (-)	-52 bp
Tssr4434	Chr14:55995912-55995917 (-)	-34 bp
Tssr4433	Chr14:55995895-55995902 (-)	-18 bp
Tssr128883	Chr14:55995800-55995893 (-)	34 bp
Tssr128882	Chr14:55995788-55995799 (-)	87 bp
Tssr128881	Chr14:55995765-55995770 (-)	113 bp
Tssr4432	Chr14:55995427-55995445 (-)	445 bp
Tssr128880	Chr14:55991911-55991939 (-)	3,956 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24