Cidea MGI Mouse Gene Detail - MGI:1270845 - cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

Symbol

Cidea
Name

cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

Feature Type

protein coding gene
IDs

MGI:1270845
NCBI Gene: 12683
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr18:67476674-67500855 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 39.94 cM
Mapping Data

2 experiments

SNPs within 2kb

913 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1270845	protein coding gene	Chr18:67476634-67500864 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024522	protein coding gene	Chr18:67621848-67652064 (+)
A/J	MGP_AJ_G0024489	protein coding gene	Chr18:64672326-64697713 (+)
AKR/J	MGP_AKRJ_G0024459	protein coding gene	Chr18:66571713-66597517 (+)
BALB/cJ	MGP_BALBcJ_G0024488	protein coding gene	Chr18:64839034-64864898 (+)
C3H/HeJ	MGP_C3HHeJ_G0024256	protein coding gene	Chr18:66723506-66749728 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024935	protein coding gene	Chr18:69419912-69444732 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022366	protein coding gene	Chr18:64048832-64073537 (+)
CAST/EiJ	MGP_CASTEiJ_G0023729	protein coding gene	Chr18:66722623-66751125 (+)
CBA/J	MGP_CBAJ_G0024226	protein coding gene	Chr18:71799858-71833214 (+)
DBA/2J	MGP_DBA2J_G0024356	protein coding gene	Chr18:64323579-64349743 (+)
FVB/NJ	MGP_FVBNJ_G0024322	protein coding gene	Chr18:63696605-63724004 (+)
LP/J	MGP_LPJ_G0024440	protein coding gene	Chr18:67483240-67520668 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024351	protein coding gene	Chr18:73079810-73104621 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024982	protein coding gene	Chr18:66733382-66761854 (+)
PWK/PhJ	MGP_PWKPhJ_G0023472	protein coding gene	Chr18:64599697-64629060 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023277	protein coding gene	Chr18:66897465-66920604 (+)
WSB/EiJ	MGP_WSBEiJ_G0023793	protein coding gene	Chr18:66629783-66666370 (+)

Human Ortholog

CIDEA, cell death inducing DFFA like effector a

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CIDEA, cell death inducing DFFA like effector a
Synonyms

CIDE-A
Links

HGNC:1976

NCBI Gene ID: 1149

neXtProt AC: NX_O60543

UniProt: O60543
Chr Location

18p11.21; chr18:12254361-12277595 (+) GRCh38

MGI Vertebrate Homology

Cidea stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CIDEA
Gene Tree

Cidea

Diseases

1 with human CIDEA associations

				Human Disease	Mouse Models
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

29 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Gene trapped

16
Targeted

5
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice show higher metabolic rate, lipolysis in BAT and core body temperature when subjected to cold treatment. They are lean and resistant to diet-induced obesity. Aging homozygotes exhibit dry eyes and hair, reduced sebaceous lipid secretion, hair loss, and poor water repulsion.

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All GO Annotations

34
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

9
cDNA Data

60
Literature Summary

33

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cidea

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS37846.1

Ensembl

ENSMUSG00000024526 (Evidence)
NCBI Gene

12683

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024526	Ensembl Gene Model \| MGI Sequence Detail	24182	C57BL/6J	± kb
transcript	ENSMUST00000025404	Ensembl \| MGI Sequence Detail	1115	Not Applicable
polypeptide	ENSMUSP00000025404	Ensembl \| MGI Sequence Detail	217	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005492 lipid transferase CIDEA

(term hierarchy)
InterPro Domains

IPR003508 CIDE-N domain

IPR032936 Lipid transferase CIDEA, N-terminal

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All nucleic 67

cDNA 60

Primer pair 6

Other 1

Microarray probesets 3

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MGI:2147356

Summaries

All 89

Developmental Gene Expression 33

Gene Ontology 17

Phenotypes 17
Earliest

J:47647 Inohara N, et al., CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998 May 1;17(9):2526-33
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cidea:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151734	Chr18:67476664-67476675 (+)	-4 bp
Tssr151735	Chr18:67476823-67476834 (+)	155 bp
Tssr151736	Chr18:67476853-67476872 (+)	189 bp
Tssr151737	Chr18:67496844-67496846 (+)	20,171 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24