Alox12b MGI Mouse Gene Detail - MGI:1274782 - arachidonate 12-lipoxygenase, 12R type

Symbol

Alox12b
Name

arachidonate 12-lipoxygenase, 12R type
Synonyms

12R-LOX, Aloxe2, e-LOX2

Feature Type

protein coding gene
IDs

MGI:1274782
NCBI Gene: 11686
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:69047898-69060617 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.38 cM
Mapping Data

4 experiments

SNPs within 2kb

439 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1274782	protein coding gene	Chr11:69047815-69060618 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018522	protein coding gene	Chr11:69566494-69580174 (+)
A/J	MGP_AJ_G0018491	protein coding gene	Chr11:66948846-66962680 (+)
AKR/J	MGP_AKRJ_G0018460	protein coding gene	Chr11:68953301-68966095 (+)
BALB/cJ	MGP_BALBcJ_G0018462	protein coding gene	Chr11:67269913-67283027 (+)
C3H/HeJ	MGP_C3HHeJ_G0018275	protein coding gene	Chr11:68970014-68983645 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018914	protein coding gene	Chr11:71679522-71692386 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016558	protein coding gene	Chr11:63889631-63902756 (+)
CAST/EiJ	MGP_CASTEiJ_G0017831	protein coding gene	Chr11:69207010-69222916 (+)
CBA/J	MGP_CBAJ_G0018249	protein coding gene	Chr11:74890112-74902910 (+)
DBA/2J	MGP_DBA2J_G0018358	protein coding gene	Chr11:66548043-66562125 (+)
FVB/NJ	MGP_FVBNJ_G0018348	protein coding gene	Chr11:66169659-66182205 (+)
LP/J	MGP_LPJ_G0018429	protein coding gene	Chr11:70149130-70162195 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018371	protein coding gene	Chr11:75515518-75531255 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018955	protein coding gene	Chr11:69200138-69212966 (+)
PWK/PhJ	MGP_PWKPhJ_G0017606	protein coding gene	Chr11:67185722-67199497 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017394	protein coding gene	Chr11:69033228-69047314 (+)
WSB/EiJ	MGP_WSBEiJ_G0017884	protein coding gene	Chr11:68840306-68854500 (+)

Human Ortholog

ALOX12B, arachidonate 12-lipoxygenase, 12R type

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALOX12B, arachidonate 12-lipoxygenase, 12R type
Synonyms

12R-LOX, ARCI2
Links

HGNC:430

NCBI Gene ID: 242

neXtProt AC: NX_O75342

UniProt: O75342
Chr Location

17p13.1; chr17:8072636-8087716 (-) GRCh38

MGI Vertebrate Homology

Alox12b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALOX12B
Gene Tree

Alox12b

Diseases

1 with human ALOX12B associations

				Human Disease	Mouse Models
				autosomal recessive congenital ichthyosis 2 IDs autosomal recessive congenital ichthyosis 2 DOID:0060710 ICD10CM:Q80.2 OMIM:242100

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 3 genetic backgrounds
4 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (ENU)

1
Chemically induced (other)

1
Targeted

4
Genomic Mutations

1 involving Alox12b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Neonatal homozygous mutant mice exhibit reddened skin that quickly dehydrates and appears scaly. The epidermis is hyperkeratotic, and its permeability barrier function is compromised. Homozygotes die within 24 hours of birth.

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All GO Annotations

45
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

828
Tissues

116
cDNA Data

15
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase alox12b

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All Sequences

32
RefSeq

2
UniProt

3
CCDS

CCDS24885.1

Ensembl

ENSMUSG00000032807 (Evidence)
NCBI Gene

11686

			Length	Strain/Species	Flank
genomic	11686	NCBI Gene Model \| MGI Sequence Detail	12720	C57BL/6J	± kb
transcript	NM_009659	RefSeq \| MGI Sequence Detail	2347	ZRU/MplStud
polypeptide	O70582	UniProt \| EBI \| MGI Sequence Detail	701	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003958 arachidonate 12-lipoxygenase, 12R-type

(term hierarchy)
EC

1.13.11.-
InterPro Domains

IPR036226 Lipoxigenase, C-terminal domain superfamily

IPR000907 Lipoxygenase

IPR020834 Lipoxygenase, conserved site

IPR013819 Lipoxygenase, C-terminal

IPR020833 Lipoxygenase, iron binding site

IPR001885 Lipoxygenase, mammalian

IPR042062 Lipoxygenase, vertebrates, PLAT domain

IPR001024 PLAT/LH2 domain

IPR036392 PLAT/LH2 domain superfamily

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All nucleic 20

Genomic 3

cDNA 15

Primer pair 2

Microarray probesets 3

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MGI:1206580

Summaries

All 50

Developmental Gene Expression 6

Gene Ontology 14

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:283668 Leiria LO, et al., 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metab. 2019 Oct 1;30(4):768-783.e7

TSS for Alox12b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102419	Chr11:69047714-69047727 (+)	-177 bp
Tssr102420	Chr11:69047739-69047742 (+)	-157 bp
Tssr102421	Chr11:69047858-69047877 (+)	-30 bp
Tssr102422	Chr11:69047879-69047887 (+)	-15 bp
Tssr102423	Chr11:69047889-69047907 (+)	0 bp
Tssr102424	Chr11:69047910-69047936 (+)	25 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24