Pfdn2 MGI Mouse Gene Detail - MGI:1276111

Symbol

Pfdn2
Name

prefoldin 2
Synonyms

ESTM27, W48336

Feature Type

protein coding gene
IDs

MGI:1276111
NCBI Gene: 18637
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:171173238-171186822 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.35 cM
Mapping Data

1 experiment

SNPs within 2kb

452 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1276111	protein coding gene	Chr1:171172522-171186822 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016757	protein coding gene	Chr1:177139995-177155304 (+)
A/J	MGP_AJ_G0016737	protein coding gene	Chr1:169921923-169935591 (+)
AKR/J	MGP_AKRJ_G0016703	protein coding gene	Chr1:175016951-175030664 (+)
BALB/cJ	MGP_BALBcJ_G0016698	protein coding gene	Chr1:170414376-170429921 (+)
C3H/HeJ	MGP_C3HHeJ_G0016521	protein coding gene	Chr1:175259258-175274909 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017159	protein coding gene	Chr1:183031275-183044772 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014867	protein coding gene	Chr1:161608795-161621609 (+)
CAST/EiJ	MGP_CASTEiJ_G0016102	protein coding gene	Chr1:174892536-174906170 (+)
CBA/J	MGP_CBAJ_G0016496	protein coding gene	Chr1:189538975-189555142 (+)
DBA/2J	MGP_DBA2J_G0016603	protein coding gene	Chr1:168763938-168778095 (+)
FVB/NJ	MGP_FVBNJ_G0016599	protein coding gene	Chr1:167113205-167126974 (+)
LP/J	MGP_LPJ_G0016674	protein coding gene	Chr1:178253668-178268609 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016626	protein coding gene	Chr1:196818347-196832951 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017196	protein coding gene	Chr1:174884508-174899478 (+)
PWK/PhJ	MGP_PWKPhJ_G0015888	protein coding gene	Chr1:167986288-168001075 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015672	protein coding gene	Chr1:173669934-173685642 (+)
WSB/EiJ	MGP_WSBEiJ_G0016164	protein coding gene	Chr1:175002366-175016509 (+)

Human Ortholog

PFDN2, prefoldin subunit 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PFDN2, prefoldin subunit 2
Synonyms

PFD2
Links

HGNC:8867

NCBI Gene ID: 5202

neXtProt AC: NX_Q9UHV9

UniProt: Q9UHV9
Chr Location

1q23.3; chr1:161100556-161118055 (-) GRCh38

MGI Vertebrate Homology

Pfdn2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PFDN2
Gene Tree

Pfdn2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

44
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

37
Targeted

2
Transgenic

1
Genomic Mutations

2 involving Pfdn2
Incidental Mutations

CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6.

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All GO Annotations

26
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pfdn2

ZFIN pfdn2

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All Sequences

38
RefSeq

6
UniProt

2
CCDS

CCDS15491.1

Ensembl

ENSMUSG00000006412 (Evidence)
NCBI Gene

18637

			Length	Strain/Species	Flank
genomic	ENSMUSG00000006412	Ensembl Gene Model \| MGI Sequence Detail	13585	C57BL/6J	± kb
transcript	ENSMUST00000135941	Ensembl \| MGI Sequence Detail	1735	Not Applicable
polypeptide	ENSMUSP00000120106	Ensembl \| MGI Sequence Detail	154	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012573 prefoldin subunit 2

(term hierarchy)
InterPro Domains

IPR009053 Prefoldin

IPR002777 Prefoldin beta-like

IPR027235 Prefoldin subunit 2
GlyGen

O70591 1 site, 1 O-linked glycan (1 site)

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All nucleic 8

Genomic 2

cDNA 5

Primer pair 1

Microarray probesets 4

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MGI:1334437

Summaries

All 33

Gene Ontology 5

Phenotypes 12
Earliest

J:48636 Vainberg IE, et al., Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell. 1998 May 29;93(5):863-73
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pfdn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10019	Chr1:171172514-171172533 (+)	-714 bp
Tssr10020	Chr1:171173237-171173248 (+)	5 bp
Tssr10021	Chr1:171173252-171173276 (+)	26 bp
Tssr10022	Chr1:171184130-171184142 (+)	10,898 bp
Tssr10023	Chr1:171185623-171185659 (+)	12,403 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24