Ep400 MGI Mouse Gene Detail - MGI:1276124

Symbol

Ep400
Name

E1A binding protein p400
Synonyms

1700020J09Rik, mDomino, mKIAA1498, p400

Feature Type

protein coding gene
IDs

MGI:1276124
NCBI Gene: 75560
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr5:110812239-110918583 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 53.69 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

1554 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1276124	protein coding gene	Chr5:110812239-110918583 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029891	protein coding gene	Chr5:113139031-113249074 (-)
A/J	MGP_AJ_G0029857	protein coding gene	Chr5:108754139-108861425 (-)
AKR/J	MGP_AKRJ_G0029795	protein coding gene	Chr5:112203176-112310623 (-)
BALB/cJ	MGP_BALBcJ_G0029868	protein coding gene	Chr5:110123265-110232559 (-)
C3H/HeJ	MGP_C3HHeJ_G0029588	protein coding gene	Chr5:112637459-112749125 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030321	protein coding gene	Chr5:117587040-117700302 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027550	protein coding gene	Chr5:103589740-103696181 (-)
CAST/EiJ	MGP_CASTEiJ_G0028996	protein coding gene	Chr5:111516282-111622554 (-)
CBA/J	MGP_CBAJ_G0029555	protein coding gene	Chr5:122013488-122122687 (-)
DBA/2J	MGP_DBA2J_G0029705	protein coding gene	Chr5:108829932-108937152 (-)
FVB/NJ	MGP_FVBNJ_G0029662	protein coding gene	Chr5:107497267-107609301 (-)
LP/J	MGP_LPJ_G0029793	protein coding gene	Chr5:113694772-113803881 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029693	protein coding gene	Chr5:126657143-126772067 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030362	protein coding gene	Chr5:111645793-111760275 (-)
PWK/PhJ	MGP_PWKPhJ_G0028710	protein coding gene	Chr5:107409593-107517706 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028548	protein coding gene	Chr5:109118404-109226162 (-)
WSB/EiJ	MGP_WSBEiJ_G0029072	protein coding gene	Chr5:112122197-112234462 (-)

Human Ortholog

EP400, E1A binding protein p400

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EP400, E1A binding protein p400
Synonyms

CAGH32, P400, TNRC12
Links

HGNC:11958

NCBI Gene ID: 57634

neXtProt AC: NX_Q96L91

UniProt: Q96L91
Chr Location

12q24.33; chr12:131949942-132080460 (+) GRCh38

MGI Vertebrate Homology

Ep400 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EP400
Gene Tree

Ep400

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Phenotype Summary

17 phenotypes from 4 alleles in 4 genetic backgrounds
1 images
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

23
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Ep400
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

142 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele die at E11.5 and display severe defects in yolk sac erythropoiesis, anemia, and a slight deformity of the neural tube.

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All GO Annotations

29
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

21
cDNA Data

213
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ep400

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All Sequences

81
RefSeq

4
UniProt

6
CCDS

CCDS19529.1, CCDS51612.1

Ensembl

ENSMUSG00000029505 (Evidence)
NCBI Gene

75560

			Length	Strain/Species	Flank
genomic	75560	NCBI Gene Model \| MGI Sequence Detail	106345	C57BL/6J	± kb
transcript	NM_029337	RefSeq \| MGI Sequence Detail	10798	Not Specified
polypeptide	Q8CHI8	UniProt \| EBI \| MGI Sequence Detail	3072	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007103 E1A-binding protein p400

(term hierarchy)
EC

3.6.4.-
InterPro Domains

IPR031575 E1A-binding protein p400, N-terminal

IPR001650 Helicase, C-terminal domain-like

IPR014012 Helicase/SANT-associated domain

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR050520 INO80/SWR1 chromatin remodeling helicase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001005 SANT/Myb domain

IPR038718 SNF2-like, N-terminal domain superfamily

IPR000330 SNF2, N-terminal

IPR049730 SNF2/RAD5-like, C-terminal helicase domain
GlyGen

Q8CHI8 33 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (32 sites)

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All nucleic 213

cDNA 213

Microarray probesets 11

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MGI:1922810, MGI:2141071

Summaries

All 65

Developmental Gene Expression 7

Gene Ontology 10

Phenotypes 25
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ep400:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52523	Chr5:110918724-110918789 (-)	-174 bp
Tssr52522	Chr5:110918576-110918589 (-)	0 bp
Tssr52521	Chr5:110918426-110918495 (-)	122 bp
Tssr52520	Chr5:110918068-110918077 (-)	510 bp
Tssr52519	Chr5:110918042-110918053 (-)	535 bp
Tssr52518	Chr5:110917998-110918039 (-)	564 bp
Tssr52517	Chr5:110910324-110910327 (-)	8,257 bp
Tssr52516	Chr5:110877742-110877771 (-)	40,826 bp
Tssr52515	Chr5:110830023-110830029 (-)	88,557 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24