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Ptp4a1 Gene Detail
Summary
  • Symbol
    Ptp4a1
  • Name
    protein tyrosine phosphatase 4a1
  • Synonyms
    Prl-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277096
    NCBI Gene: 19243
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:30979384-30988838 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 11.47 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277096
 protein coding gene Chr1:30979383-30988851 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015896
 protein coding gene Chr1:29149508-29163239 (-)
A/J MGP_AJ_G0015878
 protein coding gene Chr1:28451075-28459595 (-)
AKR/J MGP_AKRJ_G0015834
 protein coding gene Chr1:28762791-28772299 (-)
BALB/cJ MGP_BALBcJ_G0015833
 protein coding gene Chr1:28195492-28205733 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0014006
 protein coding gene Chr1:25981602-25991213 (-)
CAST/EiJ MGP_CASTEiJ_G0015246
 protein coding gene Chr1:28855567-28865039 (-)
CBA/J MGP_CBAJ_G0015639
 protein coding gene Chr1:31294031-31309938 (-)
DBA/2J MGP_DBA2J_G0015739
 protein coding gene Chr1:27899430-27908801 (-)
FVB/NJ MGP_FVBNJ_G0015742
 protein coding gene Chr1:27460684-27475254 (-)
LP/J MGP_LPJ_G0015810
 protein coding gene Chr1:29447782-29455993 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015762
 protein coding gene Chr1:33391120-33402566 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016334
 protein coding gene Chr1:28738964-28749370 (-)
PWK/PhJ MGP_PWKPhJ_G0015029
 protein coding gene Chr1:27562239-27571951 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0015310
 protein coding gene Chr1:28693448-28703463 (-)



Homology
more
  • Human Ortholog
    PTP4A1, protein tyrosine phosphatase 4A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTP4A1, protein tyrosine phosphatase 4A1
  • Synonyms
    HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1
  • Links
    NCBI Gene ID: 7803
    neXtProt AC: NX_Q93096
    UniProt: Q93096

  • Chr Location
    6q12; chr6:63516440-63583588 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A homozygous null mutation leads to an increase in preweaning lethality. Homozygous KO in combination with homozygous KO of Ptp4a2 is embryonic lethal. Heterozygous-homozygous and homozygous-heterozygous KO combinations lead to reduced male fertility, with the het-hom combination exacerbating the phenotype of single homozygous Ptp4a2 KO.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    163
  • Tissues
    28
  • cDNA Data
    28
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19243 NCBI Gene Model | MGI Sequence Detail 9455 C57BL/6J ±  kb
    transcript NM_001420788 RefSeq | MGI Sequence Detail 4255 C57BL/6  
    polypeptide Q63739 UniProt | EBI | MGI Sequence Detail 173 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 29
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138452, MGI:2138775
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:44686 Diamond RH, et al., PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Mol Cell Biol. 1994 Jun;14(6):3752-62
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory