About   Help   FAQ
Ldlrad4 Gene Detail
Summary
  • Symbol
    Ldlrad4
  • Name
    low density lipoprotein receptor class A domain containing 4
  • Synonyms
    8230401C20Rik, A430108L08Rik, D18Ertd653e, D330030L18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277150
    NCBI Gene: 52662
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:68065345-68393621 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 40.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277150
 protein coding gene Chr18:68065345-68401701 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024532
 protein coding gene Chr18:68345522-68600440 (+)
A/J MGP_AJ_G0024499
 protein coding gene Chr18:65292552-65620463 (+)
AKR/J MGP_AKRJ_G0024470
 protein coding gene Chr18:67201830-67535966 (+)
BALB/cJ MGP_BALBcJ_G0024499
 protein coding gene Chr18:65451531-65784075 (+)
C3H/HeJ MGP_C3HHeJ_G0024267
 protein coding gene Chr18:67349615-67674528 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024945
 protein coding gene Chr18:70059695-70391803 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022376
 protein coding gene Chr18:64656479-64972885 (+)
CAST/EiJ MGP_CASTEiJ_G0023740
 protein coding gene Chr18:67378754-67712216 (+)
CBA/J MGP_CBAJ_G0024236
 protein coding gene Chr18:72474040-72819106 (+)
DBA/2J MGP_DBA2J_G0024366
 protein coding gene Chr18:64921516-65242720 (+)
FVB/NJ MGP_FVBNJ_G0024332
 protein coding gene Chr18:64294908-64617865 (+)
LP/J MGP_LPJ_G0024450
 protein coding gene Chr18:68125931-68461068 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024362
 protein coding gene Chr18:73737733-74071366 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024993
 protein coding gene Chr18:67370582-67700430 (+)
PWK/PhJ MGP_PWKPhJ_G0023484
 protein coding gene Chr18:65226796-65554521 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023288
 protein coding gene Chr18:67529484-67860574 (+)
WSB/EiJ MGP_WSBEiJ_G0023803
 protein coding gene Chr18:67279300-67616751 (+)



Homology
more
  • Human Ortholog
    LDLRAD4, low density lipoprotein receptor class A domain containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LDLRAD4, low density lipoprotein receptor class A domain containing 4
  • Synonyms
    C18orf1
  • Links
    NCBI Gene ID: 753
    neXtProt AC: NX_O15165
    UniProt: O15165

  • Chr Location
    18p11.21; chr18:13217498-13652755 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52662 NCBI Gene Model | MGI Sequence Detail 328277 C57BL/6J ±  kb
    transcript NM_172631 RefSeq | MGI Sequence Detail 2577 ZRU/MplStud  
    polypeptide Q8BWJ4 UniProt | EBI | MGI Sequence Detail 306 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000034836 low-density lipoprotein receptor class A domain-containing protein 4
      (term hierarchy)
    • InterPro Domains
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR043445 TMEPAI family
    • GlyGen
      Q8BWJ4 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1924743, MGI:2443445, MGI:2451131
    References
    more
    • Summaries
      All 42
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory