Cdk6 MGI Mouse Gene Detail - MGI:1277162 - cyclin dependent kinase 6

Symbol

Cdk6
Name

cyclin dependent kinase 6
Synonyms

Crk2

Feature Type

protein coding gene
IDs

MGI:1277162
NCBI Gene: 12571
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr5:3391485-3581008 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 2.04 cM, cytoband A2-A3
Mapping Data

5 experiments

SNPs within 2kb

4116 from dbSNP Build 142
Strain Annotations

17
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277162	protein coding gene	Chr5:3391004-3581008 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029255	protein coding gene	Chr5:182886-336759 (+)
A/J	MGP_AJ_G0029220	protein coding gene	Chr5:7155-218113 (+)
AKR/J	MGP_AKRJ_G0029168	protein coding gene	Chr5:46089-216269 (+)
BALB/cJ	MGP_BALBcJ_G0029236	protein coding gene	Chr5:189396-450738 (+)
C3H/HeJ	MGP_C3HHeJ_G0028957	protein coding gene	Chr5:192060-386407 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029686	protein coding gene	Chr5:353162-591119 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026928	protein coding gene	Chr5:14125-250652 (+)
CAST/EiJ	MGP_CASTEiJ_G0028369	protein coding gene	Chr5:154810-392706 (+)
CBA/J	MGP_CBAJ_G0028919	protein coding gene	Chr5:238189-483768 (+)
DBA/2J	MGP_DBA2J_G0029068	protein coding gene	Chr5:120910-205937 (+)
FVB/NJ	MGP_FVBNJ_G0029031	protein coding gene	Chr5:117397-280943 (+)
LP/J	MGP_LPJ_G0029158	protein coding gene	Chr5:88827-375302 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029058	protein coding gene	Chr5:76497-293503 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029717	protein coding gene	Chr5:117173-341050 (+)
PWK/PhJ	MGP_PWKPhJ_G0028090	protein coding gene	Chr5:191575-351979 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0028449	protein coding gene	Chr5:217052-365843 (+)

Human Ortholog

CDK6, cyclin dependent kinase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK6, cyclin dependent kinase 6
Synonyms

MCPH12, PLSTIRE
Links

HGNC:1777

NCBI Gene ID: 1021

neXtProt AC: NX_Q00534

UniProt: Q00534
Chr Location

7q21.2; chr7:92604921-92836573 (-) GRCh38

MGI Vertebrate Homology

Cdk6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK6
Gene Tree

Cdk6

Diseases

5 with human CDK6 associations

				Human Disease	Mouse Models
				high grade glioma IDs high grade glioma DOID:3070 DOID:2627 KEGG:05214 MESH:D005910 NCI:C3059 NCI:C4822 OMIM:PS137800 ORDO:182067 UMLS_CUI:C0017638 UMLS_CUI:C0555198
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				pancreatic adenocarcinoma IDs pancreatic adenocarcinoma DOID:4074 NCI:C8294 UMLS_CUI:C0281361
				pancreatic ductal carcinoma IDs pancreatic ductal carcinoma DOID:3587 DOID:10023 ICD10CM:C25.3 ICD9CM:157.3 MESH:D021441 UMLS_CUI:C0153461 UMLS_CUI:C0887833
				primary autosomal recessive microcephaly 12 IDs primary autosomal recessive microcephaly 12 DOID:0070284 OMIM:616080

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

48 phenotypes from 7 alleles in 5 genetic backgrounds
29 phenotypes from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Endonuclease-mediated

3
Gene trapped

13
Targeted

15
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display hematopoietic abnormalities affecting spleen and thymus size. Female body weight and fertility are also reduced.

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All GO Annotations

91
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

913
Tissues

86
cDNA Data

20
Literature Summary

47

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDK6

Xenbase cdk6

ZFIN cdk6

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All Sequences

62
RefSeq

4
UniProt

6
CCDS

CCDS19062.1

Ensembl

ENSMUSG00000040274 (Evidence)
NCBI Gene

12571

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040274	Ensembl Gene Model \| MGI Sequence Detail	189524	C57BL/6J	± kb
transcript	ENSMUST00000165117	Ensembl \| MGI Sequence Detail	11525	Not Applicable
polypeptide	ENSMUSP00000126024	Ensembl \| MGI Sequence Detail	326	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005264 cyclin-dependent kinase 6

(term hierarchy)
EC

2.7.11.22
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR028788 Cyclin-dependent kinase 6

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 30

Genomic 1

cDNA 22

Primer pair 6

Other 1

Microarray probesets 5

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MGD-MRK-2146, MGI:2140921, MGI:88503

Summaries

All 149

Developmental Gene Expression 47

Diseases 1

Gene Ontology 18

Phenotypes 39
Earliest

J:19713 Meyerson M, et al., A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17
Latest

J:357398 Mayer IM, et al., Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells. Blood. 2024 Jul 11;144(2):156-170

TSS for Cdk6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1410	Chr5:3390965-3390970 (+)	-517 bp
Tssr45034	Chr5:3391196-3391211 (+)	-281 bp
Tssr45035	Chr5:3391437-3391466 (+)	-33 bp
Tssr45036	Chr5:3391477-3391485 (+)	-4 bp
Tssr45037	Chr5:3391522-3391547 (+)	50 bp
Tssr45038	Chr5:3393907-3393945 (+)	2,441 bp
Tssr45039	Chr5:3394194-3394241 (+)	2,733 bp
Tssr45040	Chr5:3524943-3524956 (+)	133,465 bp
Tssr45041	Chr5:3529707-3529724 (+)	138,231 bp
Tssr45042	Chr5:3544611-3544651 (+)	153,146 bp
Tssr1411	Chr5:3544921-3544934 (+)	153,443 bp
Tssr45043	Chr5:3547841-3547877 (+)	156,374 bp
Tssr45044	Chr5:3551997-3552008 (+)	160,518 bp
Tssr45045	Chr5:3552045-3552053 (+)	160,564 bp
Tssr45046	Chr5:3552804-3552835 (+)	161,335 bp
Tssr45047	Chr5:3565189-3565238 (+)	173,729 bp
Tssr45048	Chr5:3571581-3571601 (+)	180,106 bp
Tssr45049	Chr5:3572260-3572265 (+)	180,778 bp
Tssr45050	Chr5:3577058-3577093 (+)	185,591 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24