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Arhgef25 Gene Detail
Summary
  • Symbol
    Arhgef25
  • Name
    Rho guanine nucleotide exchange factor 25
  • Synonyms
    2410008H17Rik, D10Ertd610e, GEFT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277173
    NCBI Gene: 52666
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127018394-127025952 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    206 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277173
 protein coding gene Chr10:127018390-127025952 (-)
129S1/SvImJ ENSMUSGG00200054462
 protein coding gene Chr10:123375328-123378054 (-)
129S1/SvImJ ENSMUSG00200009868
 protein coding gene Chr10:123375442-123375542 (-)
A/J ENSMUSG00195014502
 protein coding gene Chr10:123840171-123840271 (-)
A/J ENSMUSGG00195055100
 protein coding gene Chr10:123840057-123842782 (-)
AKR/J ENSMUSGG00220054644
 protein coding gene Chr10:123443945-123446671 (-)
AKR/J ENSMUSG00220004463
 protein coding gene Chr10:123444059-123444159 (-)
BALB/cJ ENSMUSGG00180055545
 protein coding gene Chr10:123831130-123833855 (-)
BALB/cJ ENSMUSG00180009700
 protein coding gene Chr10:123831244-123831344 (-)
C3H/HeJ ENSMUSG00175005526
 protein coding gene Chr10:123829482-123829582 (-)
C3H/HeJ ENSMUSGG00175055104
 protein coding gene Chr10:123829368-123832094 (-)
C57BL/6NJ ENSMUSG00215012148
 protein coding gene Chr10:123441262-123441362 (-)
C57BL/6NJ ENSMUSGG00215055739
 protein coding gene Chr10:123441148-123443873 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015884
 protein coding gene Chr10:119535785-119543359 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054537
 protein coding gene Chr10:123653551-123656277 (-)
CBA/J ENSMUSG00210008229
 protein coding gene Chr10:123653665-123653765 (-)
DBA/2J ENSMUSG00185026918
 protein coding gene Chr10:123806072-123806172 (-)
DBA/2J ENSMUSGG00185057553
 protein coding gene Chr10:123805958-123808684 (-)
FVB/NJ ENSMUSG00205012598
 protein coding gene Chr10:123050089-123050189 (-)
FVB/NJ ENSMUSGG00205054557
 protein coding gene Chr10:123049975-123052701 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055421
 protein coding gene Chr10:125723193-125725918 (-)
LP/J ENSMUSG00230025042
 protein coding gene Chr10:125723307-125723407 (-)
NOD/ShiLtJ ENSMUSGG00190054699
 protein coding gene Chr10:123872481-123875207 (-)
NOD/ShiLtJ ENSMUSG00190015753
 protein coding gene Chr10:123872595-123872695 (-)
NZO/HlLtJ ENSMUSGG00225055201
 protein coding gene Chr10:129923225-129925951 (-)
NZO/HlLtJ ENSMUSG00225035503
 protein coding gene Chr10:129923339-129923439 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010033649
 protein coding gene Chr10:125507480-125515103 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ARHGEF25, Rho guanine nucleotide exchange factor 25
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF25, Rho guanine nucleotide exchange factor 25
  • Synonyms
    GEFT, p63RhoGEF
  • Links
    NCBI Gene ID: 115557
    UniProt: Q86VW2

  • Chr Location
    12q13.3; chr12:57610116-57617245 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a conditional allele activated in the second heart field exhibit normal cardiac development and prenatal survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    703
  • Tissues
    72
  • cDNA Data
    73
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019467 Ensembl Gene Model | MGI Sequence Detail 7559 C57BL/6J ±  kb
transcript ENSMUST00000019611 Ensembl | MGI Sequence Detail 2218 Not Applicable  
polypeptide ENSMUSP00000019611 Ensembl | MGI Sequence Detail 618 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    cDNA 73
    Primer pair 3
    Antibodies 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1919219
References
more
  • Summaries
    All 47
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory