Cpsf4l MGI Mouse Gene Detail - MGI:1277182 - cleavage and polyadenylation specific factor 4-like

Symbol

Cpsf4l
Name

cleavage and polyadenylation specific factor 4-like
Synonyms

0610010C04Rik, 1500000C01Rik, D11Ertd636e

Feature Type

protein coding gene
IDs

MGI:1277182
NCBI Gene: 52670
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:113588998-113600843 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 79.17 cM
Mapping Data

3 experiments

SNPs within 2kb

565 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277182	protein coding gene	Chr11:113588997-113601125 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019353	protein coding gene	Chr11:117528615-117540645 (-)
A/J	MGP_AJ_G0019322	protein coding gene	Chr11:112466222-112478804 (-)
AKR/J	MGP_AKRJ_G0019290	protein coding gene	Chr11:115776166-115788381 (-)
BALB/cJ	MGP_BALBcJ_G0019295	protein coding gene	Chr11:112874841-112887948 (-)
C3H/HeJ	MGP_C3HHeJ_G0019104	protein coding gene	Chr11:116130194-116143609 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019746	protein coding gene	Chr11:121053271-121066331 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017369	protein coding gene	Chr11:109542640-109555038 (-)
CAST/EiJ	MGP_CASTEiJ_G0018658	protein coding gene	Chr11:117400536-117416054 (-)
CBA/J	MGP_CBAJ_G0019074	protein coding gene	Chr11:125985497-125999311 (-)
DBA/2J	MGP_DBA2J_G0019186	protein coding gene	Chr11:111902479-111914917 (-)
FVB/NJ	MGP_FVBNJ_G0019177	protein coding gene	Chr11:111380900-111392692 (-)
LP/J	MGP_LPJ_G0019256	protein coding gene	Chr11:117969069-117981624 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019208	protein coding gene	Chr11:125136547-125153359 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019783	protein coding gene	Chr11:116428402-116444485 (-)
PWK/PhJ	MGP_PWKPhJ_G0018423	protein coding gene	Chr11:113114623-113127336 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018215	protein coding gene	Chr11:116237132-116250611 (-)
WSB/EiJ	MGP_WSBEiJ_G0018710	protein coding gene	Chr11:116388524-116401350 (-)

Human Ortholog

CPSF4L, cleavage and polyadenylation specific factor 4 like

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPSF4L, cleavage and polyadenylation specific factor 4 like
Links

HGNC:33632

NCBI Gene ID: 642843

neXtProt AC: NX_A6NMK7

UniProt: A6NMK7
Chr Location

17q25.1; chr17:73242101-73263778 (-) GRCh38

MGI Vertebrate Homology

Cpsf4l stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CPSF4L
Gene Tree

Cpsf4l

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

60
Endonuclease-mediated

2
Gene trapped

57
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

64 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

29
cDNA Data

25
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cpsf4l

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All Sequences

93
RefSeq

44
UniProt

8
CCDS

CCDS25602.1, CCDS25603.2, CCDS48977.1

Ensembl

ENSMUSG00000018727 (Evidence)
NCBI Gene

52670

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018727	Ensembl Gene Model \| MGI Sequence Detail	11846	C57BL/6J	± kb
transcript	ENSMUST00000100248	Ensembl \| MGI Sequence Detail	1375	Not Applicable
polypeptide	ENSMUSP00000097819	Ensembl \| MGI Sequence Detail	280	Not Applicable

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UniProt

8 Sequences
InterPro Domains

IPR045348 CPSF complex subunit CPSF4-like

IPR000571 Zinc finger, CCCH-type

IPR036855 Zinc finger, CCCH-type superfamily

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All nucleic 26

cDNA 25

Primer pair 1

Microarray probesets 4

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MGI:1915590, MGI:1924153

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cpsf4l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111646	Chr11:113600934-113600939 (-)	-94 bp
Tssr111645	Chr11:113600924-113600931 (-)	-85 bp
Tssr111644	Chr11:113600879-113600887 (-)	-40 bp
Tssr111643	Chr11:113600838-113600849 (-)	-1 bp
Tssr111642	Chr11:113600479-113600516 (-)	345 bp
Tssr111641	Chr11:113600347-113600354 (-)	492 bp
Tssr111640	Chr11:113599778-113599798 (-)	1,055 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24