Atg5 MGI Mouse Gene Detail - MGI:1277186

Symbol

Atg5
Name

autophagy related 5
Synonyms

2010107M05Rik, 3110067M24Rik, Apg5l, Paddy

Feature Type

protein coding gene
IDs

MGI:1277186
NCBI Gene: 11793
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:44144354-44240287 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 23.24 cM
Mapping Data

3 experiments

SNPs within 2kb

2108 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277186	protein coding gene	Chr10:44144325-44240295 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017204	protein coding gene	Chr10:43111268-43217067 (+)
A/J	MGP_AJ_G0017180	protein coding gene	Chr10:41891692-41992976 (+)
AKR/J	MGP_AKRJ_G0017139	protein coding gene	Chr10:42564251-42660728 (+)
BALB/cJ	MGP_BALBcJ_G0017141	protein coding gene	Chr10:41955780-42051242 (+)
C3H/HeJ	MGP_C3HHeJ_G0016965	protein coding gene	Chr10:42874858-42972753 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017599	protein coding gene	Chr10:44422475-44527605 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015294	protein coding gene	Chr10:39816214-39910389 (+)
CAST/EiJ	MGP_CASTEiJ_G0016539	protein coding gene	Chr10:43118017-43222694 (+)
CBA/J	MGP_CBAJ_G0016936	protein coding gene	Chr10:46425526-46540011 (+)
DBA/2J	MGP_DBA2J_G0017041	protein coding gene	Chr10:41331125-41428231 (+)
FVB/NJ	MGP_FVBNJ_G0017035	protein coding gene	Chr10:40841915-40936689 (+)
LP/J	MGP_LPJ_G0017116	protein coding gene	Chr10:43133575-43245253 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017064	protein coding gene	Chr10:47123013-47224865 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017635	protein coding gene	Chr10:42557182-42664597 (+)
PWK/PhJ	MGP_PWKPhJ_G0016318	protein coding gene	Chr10:41281341-41385449 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016103	protein coding gene	Chr10:42387521-42484544 (+)
WSB/EiJ	MGP_WSBEiJ_G0016602	protein coding gene	Chr10:42811324-42909887 (+)

Human Ortholog

ATG5, autophagy related 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATG5, autophagy related 5
Synonyms

APG5, APG5L, APG5-LIKE, ASP, hAPG5, SCAR25
Links

HGNC:589

NCBI Gene ID: 9474

neXtProt AC: NX_Q9H1Y0

UniProt: Q9H1Y0
Chr Location

6q21; chr6:106045423-106325791 (-) GRCh38

MGI Vertebrate Homology

Atg5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATG5
Gene Tree

Atg5

Diseases

1 with Atg5 mouse models; 1 with human ATG5 associations

Human Disease

Mouse Models

systemic lupus erythematosus

IDs

View 1 model

autosomal recessive spinocerebellar ataxia 25

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

127 phenotypes from 4 alleles in 20 genetic backgrounds
13 phenotypes from multigenic genotypes
4 images
381 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

18
Radiation induced

1
Targeted

3
Transgenic

1
Genomic Mutations

2 involving Atg5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutation of this gene results in impaired autophagy due to absence of autolysosomes. Homozygotes die within 1 day of birth, and have shorter survival times and reduced amino acid levels under fasting conditions. Homozygotes for a gene trap insertion mutationin this gene show no abnormal phenotype. A kidney proximal tubular cell-specific KO allele exacerbates renal inflammation in mice subjected to unilateral ureteric obstruction.

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All GO Annotations

104
GO References

38

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

55
cDNA Data

80
Literature Summary

26

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atg5

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All Sequences

64
RefSeq

22
UniProt

3
CCDS

CCDS23824.1

Ensembl

ENSMUSG00000038160 (Evidence)
NCBI Gene

11793

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038160	Ensembl Gene Model \| MGI Sequence Detail	95934	C57BL/6J	± kb
transcript	ENSMUST00000039286	Ensembl \| MGI Sequence Detail	2352	Not Applicable
polypeptide	ENSMUSP00000044769	Ensembl \| MGI Sequence Detail	275	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004418 autophagy protein 5

(term hierarchy)
InterPro Domains

IPR048940 Autophagy protein ATG5, alpha-helical bundle region

IPR042526 Autophagy protein Atg5, helix rich domain

IPR048939 Autophagy protein ATG5, UblA domain

IPR042527 Autophagy protein Atg5, UblA domain superfamily

IPR048318 Autophagy protein ATG5, UblB domain

IPR007239 Autophagy-related protein 5

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All nucleic 83

cDNA 81

Primer pair 2

Microarray probesets 5

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MGI:1277148, MGI:1917267, MGI:1920439, MGI:2143833, MGI:2143950

Summaries

All 524

Developmental Gene Expression 26

Diseases 1

Gene Ontology 38

Phenotypes 381
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:359740 Li S, et al., ATG5 attenuates inflammatory signaling in mouse embryonic stem cells to control differentiation. Dev Cell. 2024 Feb 14;

TSS for Atg5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93164	Chr10:44144324-44144375 (+)	-4 bp
Tssr93165	Chr10:44144385-44144404 (+)	41 bp
Tssr93166	Chr10:44144418-44144441 (+)	76 bp
Tssr93167	Chr10:44144444-44144524 (+)	130 bp
Tssr93168	Chr10:44146244-44146249 (+)	1,893 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24