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Fhit Gene Detail
Summary
  • Symbol
    Fhit
  • Name
    fragile histidine triad gene
  • Synonyms
    Fra14A2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277947
    NCBI Gene: 14198
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:11307738-12919681 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 5.61 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45550 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277947
 protein coding gene Chr14:11307718-12919681 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020995
 protein coding gene Chr14:1889698-3514502 (-)
A/J MGP_AJ_G0020943
 protein coding gene Chr14:1858618-3467318 (-)
AKR/J MGP_AKRJ_G0020920
 protein coding gene Chr14:1868392-3510309 (-)
BALB/cJ MGP_BALBcJ_G0020946
 protein coding gene Chr14:1857544-3458100 (-)
C3H/HeJ MGP_C3HHeJ_G0020730
 protein coding gene Chr14:1886165-3547368 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021379
 protein coding gene Chr14:1973392-3650539 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018948
 protein coding gene Chr14:2711864-4231100 (-)
CAST/EiJ MGP_CASTEiJ_G0020252
 protein coding gene Chr14:1903370-3519063 (-)
CBA/J MGP_CBAJ_G0020696
 protein coding gene Chr14:2063844-3762494 (-)
DBA/2J MGP_DBA2J_G0020819
 protein coding gene Chr14:1829107-3411820 (-)
FVB/NJ MGP_FVBNJ_G0020801
 protein coding gene Chr14:1799815-3383297 (-)
LP/J MGP_LPJ_G0020896
 protein coding gene Chr14:1870474-3460871 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020827
 protein coding gene Chr14:2065411-3850349 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021412
 protein coding gene Chr14:1848642-3465099 (-)
PWK/PhJ MGP_PWKPhJ_G0020004
 protein coding gene Chr14:1860350-3437075 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019825
 protein coding gene Chr14:1917827-3559932 (-)
WSB/EiJ MGP_WSBEiJ_G0020310
 protein coding gene Chr14:1922211-3518707 (-)



Homology
more
  • Human Ortholog
    FHIT, fragile histidine triad diadenosine triphosphatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FHIT, fragile histidine triad diadenosine triphosphatase
  • Synonyms
    AP3Aase, FRA3B
  • Links
    NCBI Gene ID: 2272
    neXtProt AC: NX_P49789
    UniProt: P49789

  • Chr Location
    3p14.2; chr3:59747277-61251459 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fhit mouse models; 7 with human FHIT associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Both homozygotes and heterozygotes for a targeted null mutation exhibit a similarly increased incidence of both spontaneous and nitrosomethylbenzalamine-induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    105
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060579 Ensembl Gene Model | MGI Sequence Detail 1611944 C57BL/6J ±  kb
    transcript ENSMUST00000160340 Ensembl | MGI Sequence Detail 1094 Not Applicable  
    polypeptide ENSMUSP00000124017 Ensembl | MGI Sequence Detail 213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145783
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:113676 Barnes LD, et al., Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5'-P1,P3-triphosphate hydrolase. Biochemistry. 1996 Sep 10;35(36):11529-35
    • Latest
      J:194670 Saldivar JC, et al., Initiation of genome instability and preneoplastic processes through loss of Fhit expression. PLoS Genet. 2012 Nov;8(11):e1003077
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory