Pcm1 MGI Mouse Gene Detail - MGI:1277958 - pericentriolar material 1

Symbol

Pcm1
Name

pericentriolar material 1
Synonyms

2600002H09Rik, 9430077F19Rik, C030044G17Rik

Feature Type

protein coding gene
IDs

MGI:1277958
NCBI Gene: 18536
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr8:41692789-41785381 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 23.89 cM
Mapping Data

4 experiments

SNPs within 2kb

1397 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277958	protein coding gene	Chr8:41692521-41787125 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033561	protein coding gene	Chr8:40069666-40167061 (+)
A/J	MGP_AJ_G0033544	protein coding gene	Chr8:38549884-38646225 (+)
AKR/J	MGP_AKRJ_G0033467	protein coding gene	Chr8:39709352-39805224 (+)
BALB/cJ	MGP_BALBcJ_G0033539	protein coding gene	Chr8:38667242-38763611 (+)
C3H/HeJ	MGP_C3HHeJ_G0033249	protein coding gene	Chr8:40102124-40199825 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034055	protein coding gene	Chr8:41597007-41694168 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031004	protein coding gene	Chr8:35199502-35291522 (+)
CAST/EiJ	MGP_CASTEiJ_G0032577	protein coding gene	Chr8:39599509-39699211 (+)
CBA/J	MGP_CBAJ_G0033227	protein coding gene	Chr8:43306381-43405214 (+)
DBA/2J	MGP_DBA2J_G0033381	protein coding gene	Chr8:38376131-38471287 (+)
FVB/NJ	MGP_FVBNJ_G0033325	protein coding gene	Chr8:37960951-38057323 (+)
LP/J	MGP_LPJ_G0033470	protein coding gene	Chr8:40105630-40208355 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033367	protein coding gene	Chr8:43056112-43188907 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034073	protein coding gene	Chr8:39862030-39964264 (+)
PWK/PhJ	MGP_PWKPhJ_G0032286	protein coding gene	Chr8:37924834-38022909 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032118	protein coding gene	Chr8:39030130-39130730 (+)
WSB/EiJ	MGP_WSBEiJ_G0032692	protein coding gene	Chr8:40071127-40169620 (+)

Human Ortholog

PCM1, pericentriolar material 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PCM1, pericentriolar material 1
Synonyms

PTC4, RET/PCM-1
Links

HGNC:8727

NCBI Gene ID: 5108

neXtProt AC: NX_Q15154

UniProt: Q15154
Chr Location

8p22; chr8:17922842-18029948 (+) GRCh38

MGI Vertebrate Homology

Pcm1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PCM1
Gene Tree

Pcm1

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

47
Endonuclease-mediated

4
Gene trapped

41
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

92 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Haploinsufficient mice show a reduced brain size, behavioral impairment to social stimulus and reduced rearing in the open field test.

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All GO Annotations

61
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

3
cDNA Data

17
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pcm1

ZFIN pcm1

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All Sequences

89
RefSeq

38
UniProt

3
CCDS

CCDS22261.1

Ensembl

ENSMUSG00000031592 (Evidence)
NCBI Gene

18536

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031592	Ensembl Gene Model \| MGI Sequence Detail	92593	C57BL/6J	± kb
transcript	ENSMUST00000211247	Ensembl \| MGI Sequence Detail	6484	Not Applicable
polypeptide	ENSMUSP00000147887	Ensembl \| MGI Sequence Detail	2064	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012419 pericentriolar material 1 protein

(term hierarchy)
InterPro Domains

IPR024138 Pericentriolar material 1 protein

IPR031446 Pericentriolar material 1 protein, C-terminal
GlyGen

Q9R0L6 12 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (10 sites)

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All nucleic 20

Genomic 1

cDNA 18

Primer pair 1

Microarray probesets 6

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MGI:1919589, MGI:1924673, MGI:1924736

Summaries

All 71

Developmental Gene Expression 13

Gene Ontology 20

Phenotypes 17
Earliest

J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
Latest

J:354224 Van Wauwe J, et al., PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates. Life Sci Alliance. 2024 Dec;7(12)

TSS for Pcm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77091	Chr8:41692610-41692696 (+)	-136 bp
Tssr77092	Chr8:41692755-41692804 (+)	-9 bp
Tssr77093	Chr8:41694020-41694056 (+)	1,249 bp
Tssr77094	Chr8:41699524-41699527 (+)	6,737 bp
Tssr77095	Chr8:41718707-41718718 (+)	25,924 bp
Tssr77096	Chr8:41733385-41733393 (+)	40,600 bp
Tssr77097	Chr8:41752167-41752170 (+)	59,380 bp
Tssr77098	Chr8:41769048-41769066 (+)	76,268 bp
Tssr77099	Chr8:41783723-41783736 (+)	90,941 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24