Nidd2 QTL Detail

Summary

• Symbol
  Nidd2
• Name
  non-insulin-dependent diabetes mellitus 2

• Feature Type
  QTL
• IDs
  MGI:1277974
  NCBI Gene: 112361
• Candidate Genes
  2 Genes

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 18, 18.04 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  112361

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:48957 Leiter EH, et al., NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes. 1998 Aug;47(8):1287-95
• Latest
  J:91835 Kaput J, et al., Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics. 2004 Aug 11;18(3):316-24

Candidate Genes for Nidd2:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Cd14	Chr18:36858120-36859851 (-)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 18, Fgf1 (19 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Nidd2 (16 cM) maps near candidate gene Fgf1. Cd14 (31 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Bwq4 (28 cM) maps near candidate gene Cd14.
Fgf1	Chr18:38971726-39062525 (-)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 18, Fgf1 (19 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Nidd2 (16 cM) maps near candidate gene Fgf1. Cd14 (31 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Bwq4 (28 cM) maps near candidate gene Cd14.