Tlq1 QTL Detail

Summary

• Symbol
  Tlq1
• Name
  telomere length QTL 1

• Feature Type
  QTL
• IDs
  MGI:1277976
  NCBI Gene: 112092
• Candidate Genes
  3 Genes

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 2, 100.95 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  112092

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:48933 Zhu L, et al., Telomere length regulation in mice is linked to a novel chromosome locus. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8648-53
• Latest
  J:91351 Ding H, et al., Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell. 2004 Jun 25;117(7):873-86

Candidate Genes for Tlq1:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Arfrp1	Chr2:180999483-181007197 (-)	J:91351	Rtel1 is a candidate gene for a previously mapped telomere length QTL named Tlq1 positioned at the distal end of mouse Chromosome 2. Rtel1/Tlq1 is located approximately 2 cM from the telomere at around 107 cM. An Rtel1 EST and cDNAs from Stmn3 and Arfrp1 hybrizided to BAC clone RP23-60M5. The order of genes at this locus is as follows: centromere - Stmn3 - Rtel1 - Arfrp1 - telomere
Rtel1	Chr2:180961532-180998409 (+)	J:91351	Rtel1 is a candidate gene for a previously mapped telomere length QTL named Tlq1 positioned at the distal end of mouse Chromosome 2. Rtel1/Tlq1 is located approximately 2 cM from the telomere at around 107 cM. An Rtel1 EST and cDNAs from Stmn3 and Arfrp1 hybrizided to BAC clone RP23-60M5. The order of genes at this locus is as follows: centromere - Stmn3 - Rtel1 - Arfrp1 - telomere
Stmn3	Chr2:180948252-180956293 (-)	J:91351	Rtel1 is a candidate gene for a previously mapped telomere length QTL named Tlq1 positioned at the distal end of mouse Chromosome 2. Rtel1/Tlq1 is located approximately 2 cM from the telomere at around 107 cM. An Rtel1 EST and cDNAs from Stmn3 and Arfrp1 hybrizided to BAC clone RP23-60M5. The order of genes at this locus is as follows: centromere - Stmn3 - Rtel1 - Arfrp1 - telomere