Fpr2 MGI Mouse Gene Detail - MGI:1278319 - formyl peptide receptor 2

Symbol

Fpr2
Name

formyl peptide receptor 2
Synonyms

E330010I07Rik, Fpr-rs2

Feature Type

protein coding gene
IDs

MGI:1278319
NCBI Gene: 14289
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr17:18108086-18114214 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 10.66 cM, cytoband A3.1
Mapping Data

3 experiments

SNPs within 2kb

203 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1278319	protein coding gene	Chr17:18108086-18114214 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023187	protein coding gene	Chr17:15894019-15906216 (+)
A/J	MGP_AJ_G0023153	protein coding gene	Chr17:15550244-15551581 (+)
AKR/J	MGP_AKRJ_G0023122	protein coding gene	Chr17:15614756-15621094 (+)
BALB/cJ	MGP_BALBcJ_G0023152	protein coding gene	Chr17:15485681-15491812 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0023595	protein coding gene	Chr17:16682921-16692946 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021107	protein coding gene	Chr17:13387171-13393403 (+)
CAST/EiJ	MGP_CASTEiJ_G0022431	protein coding gene	Chr17:15650053-15695202 (+)
CBA/J	MGP_CBAJ_G0022889	protein coding gene	Chr17:17253292-17260043 (+)
DBA/2J	MGP_DBA2J_G0023022	protein coding gene	Chr17:15253630-15259481 (+)
FVB/NJ	MGP_FVBNJ_G0022990	protein coding gene	Chr17:15067902-15075819 (+)
LP/J	MGP_LPJ_G0023096	protein coding gene	Chr17:15887943-15894077 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023011	protein coding gene	Chr17:16854773-16873078 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023632	protein coding gene	Chr17:15808222-15814260 (+)
PWK/PhJ	MGP_PWKPhJ_G0022181	protein coding gene	Chr17:14907890-14921666 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022008	protein coding gene	Chr17:14896691-14902811 (+)
WSB/EiJ	MGP_WSBEiJ_G0022490	protein coding gene	Chr17:16090415-16098587 (+)

Human Ortholog

FPR2, formyl peptide receptor 2

Vertebrate Orthologs

10

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FPR2, formyl peptide receptor 2
Synonyms

ALX, ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH1, FPRH2, FPRL1, HM63, LXA4R
Links

HGNC:3827

NCBI Gene ID: 2358

neXtProt AC: NX_P25090

UniProt: P25090
Chr Location

19q13.41; chr19:51752026-51770531 (+) GRCh38

MGI Vertebrate Homology

Fpr2 stringent orthology
1 human;1 mouse;2 rat;7 zebrafish
HCOP

vertebrate homology predictions: FPR2
Gene Tree

Fpr2

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Phenotype Summary

35 phenotypes from 4 alleles in 6 genetic backgrounds
8 images
62 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

6
Targeted

9
Transgenic

1
Genomic Mutations

1 involving Fpr2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted reporter allele exhibit altered leukocyte responses and experimentally induced inflammation.

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All GO Annotations

33
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS28419.1

Ensembl

ENSMUSG00000052270 (Evidence)
NCBI Gene

14289

			Length	Strain/Species	Flank
genomic	14289	NCBI Gene Model \| MGI Sequence Detail	6129	C57BL/6J	± kb
transcript	NM_008039	RefSeq \| MGI Sequence Detail	1296	C57BL/6
polypeptide	O88536	UniProt \| EBI \| MGI Sequence Detail	351	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR000826 Formyl peptide receptor-related

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

O88536 2 sites

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All nucleic 11

Genomic 7

cDNA 4

Microarray probesets 2

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MGI:2442028

Summaries

All 106

Gene Ontology 7

Phenotypes 62
Earliest

J:49567 Gao JL, et al., Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse. Genomics. 1998 Jul 15;51(2):270-6
Latest

J:347805 Mooney SM, et al., Behavioral changes in FPR2/ALX and Chemr23 receptor knockout mice are exacerbated by prenatal alcohol exposure. Front Neurosci. 2023;17:1187220

TSS for Fpr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142821	Chr17:18107355-18107397 (+)	-710 bp
Tssr142822	Chr17:18108069-18108080 (+)	-11 bp
Tssr142823	Chr17:18108088-18108099 (+)	8 bp
Tssr142824	Chr17:18108102-18108127 (+)	29 bp
Tssr142825	Chr17:18110206-18110222 (+)	2,128 bp
Tssr142826	Chr17:18110360-18110374 (+)	2,281 bp
Tssr142827	Chr17:18110610-18110614 (+)	2,526 bp
Tssr142828	Chr17:18110850-18110862 (+)	2,770 bp
Tssr142829	Chr17:18110871-18110892 (+)	2,796 bp
Tssr142830	Chr17:18110900-18110907 (+)	2,818 bp
Tssr142831	Chr17:18110959-18110962 (+)	2,875 bp
Tssr142832	Chr17:18111003-18111014 (+)	2,923 bp
Tssr142833	Chr17:18111676-18111688 (+)	3,596 bp
Tssr142834	Chr17:18114072-18114121 (+)	6,011 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24