Epc2 MGI Mouse Gene Detail - MGI:1278321 - enhancer of polycomb homolog 2

Symbol

Epc2
Name

enhancer of polycomb homolog 2
Synonyms

D2Ertd694e

Feature Type

protein coding gene
IDs

MGI:1278321
NCBI Gene: 227867
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:49341498-49441954 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 28.62 cM
Mapping Data

3 experiments

SNPs within 2kb

2004 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1278321	protein coding gene	Chr2:49341498-49441960 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025722	protein coding gene	Chr2:48624577-48726397 (+)
A/J	MGP_AJ_G0025698	protein coding gene	Chr2:46787441-46881555 (+)
AKR/J	MGP_AKRJ_G0025668	protein coding gene	Chr2:48127773-48228872 (+)
BALB/cJ	MGP_BALBcJ_G0025693	protein coding gene	Chr2:46904448-47000032 (+)
C3H/HeJ	MGP_C3HHeJ_G0025454	protein coding gene	Chr2:48110789-48211217 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026139	protein coding gene	Chr2:50110271-50208004 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023545	protein coding gene	Chr2:44830149-44924118 (+)
CAST/EiJ	MGP_CASTEiJ_G0024919	protein coding gene	Chr2:48173859-48271481 (+)
CBA/J	MGP_CBAJ_G0025434	protein coding gene	Chr2:51969840-52085124 (+)
DBA/2J	MGP_DBA2J_G0025565	protein coding gene	Chr2:46408960-46506508 (+)
FVB/NJ	MGP_FVBNJ_G0025527	protein coding gene	Chr2:46130396-46235897 (+)
LP/J	MGP_LPJ_G0025653	protein coding gene	Chr2:48559974-48663889 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025558	protein coding gene	Chr2:53025921-53157697 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026197	protein coding gene	Chr2:48028390-48129905 (+)
PWK/PhJ	MGP_PWKPhJ_G0024660	protein coding gene	Chr2:46292178-46384085 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024466	protein coding gene	Chr2:48196252-48298646 (+)
WSB/EiJ	MGP_WSBEiJ_G0024986	protein coding gene	Chr2:48289833-48386315 (+)

Human Ortholog

EPC2, enhancer of polycomb homolog 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPC2, enhancer of polycomb homolog 2
Synonyms

EPC-LIKE
Links

HGNC:24543

NCBI Gene ID: 26122

neXtProt AC: NX_Q52LR7

UniProt: Q52LR7
Chr Location

2q23.1; chr2:148644440-148787569 (+) GRCh38

MGI Vertebrate Homology

Epc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EPC2
Gene Tree

Epc2

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Chemically induced (other)

1
Gene trapped

35
Targeted

5
Genomic Mutations

1 involving Epc2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

82
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase epc2

ZFIN epc2

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All Sequences

49
RefSeq

4
UniProt

3
CCDS

CCDS16023.1

Ensembl

ENSMUSG00000069495 (Evidence)
NCBI Gene

227867

			Length	Strain/Species	Flank
genomic	227867	NCBI Gene Model \| MGI Sequence Detail	100457	C57BL/6J	± kb
transcript	NM_172663	RefSeq \| MGI Sequence Detail	4358	ZRU/MplStud
polypeptide	Q8C0I4	UniProt \| EBI \| MGI Sequence Detail	808	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007117 enhancer of polycomb homolog 2

(term hierarchy)
InterPro Domains

IPR009607 Enhancer of polycomb, C-terminal

IPR019542 Enhancer of polycomb-like, N-terminal

IPR024943 Enhancer of polycomb protein
GlyGen

Q8C0I4 1 site, 1 O-linked glycan (1 site)

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All nucleic 83

cDNA 82

Primer pair 1

Microarray probesets 6

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MGI:1277221

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 17
Earliest

J:43737 Stankunas K, et al., The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Development. 1998 Oct;125(20):4055-66
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Epc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17669	Chr2:49341500-49341571 (+)	38 bp
Tssr17670	Chr2:49341854-49341861 (+)	360 bp
Tssr17671	Chr2:49355941-49355943 (+)	14,444 bp
Tssr17672	Chr2:49406815-49406816 (+)	65,318 bp
Tssr17673	Chr2:49413621-49413625 (+)	72,125 bp
Tssr17674	Chr2:49417343-49417345 (+)	75,846 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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