Bcl6b MGI Mouse Gene Detail - MGI:1278332 - B cell CLL/lymphoma 6, member B

Symbol

Bcl6b
Name

B cell CLL/lymphoma 6, member B
Synonyms

Bazf

Feature Type

protein coding gene
IDs

MGI:1278332
NCBI Gene: 12029
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:70114954-70120624 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.99 cM, cytoband B4
Mapping Data

1 experiment

SNPs within 2kb

72 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1278332	protein coding gene	Chr11:70114953-70120624 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018586	protein coding gene	Chr11:70744665-70750339 (-)
A/J	MGP_AJ_G0018554	protein coding gene	Chr11:68055983-68061653 (-)
AKR/J	MGP_AKRJ_G0018523	protein coding gene	Chr11:70086465-70092135 (-)
BALB/cJ	MGP_BALBcJ_G0018526	protein coding gene	Chr11:68378759-68384429 (-)
C3H/HeJ	MGP_C3HHeJ_G0018339	protein coding gene	Chr11:70124830-70130500 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018977	protein coding gene	Chr11:72842769-72848439 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016622	protein coding gene	Chr11:64974526-64980213 (-)
CAST/EiJ	MGP_CASTEiJ_G0017894	protein coding gene	Chr11:70370431-70376114 (-)
CBA/J	MGP_CBAJ_G0018311	protein coding gene	Chr11:76153128-76158798 (-)
DBA/2J	MGP_DBA2J_G0018421	protein coding gene	Chr11:67631715-67637390 (-)
FVB/NJ	MGP_FVBNJ_G0018411	protein coding gene	Chr11:67287231-67292901 (-)
LP/J	MGP_LPJ_G0018491	protein coding gene	Chr11:71314367-71320037 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018434	protein coding gene	Chr11:76721287-76726961 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019019	protein coding gene	Chr11:70358266-70363936 (-)
PWK/PhJ	MGP_PWKPhJ_G0017668	protein coding gene	Chr11:68285301-68290965 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017458	protein coding gene	Chr11:70156118-70161804 (-)
WSB/EiJ	MGP_WSBEiJ_G0017948	protein coding gene	Chr11:70021696-70027369 (-)

Human Ortholog

BCL6B, BCL6B transcription repressor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCL6B, BCL6B transcription repressor
Synonyms

BAZF, ZBTB28, ZNF62
Links

HGNC:1002

NCBI Gene ID: 255877

neXtProt AC: NX_Q8N143

UniProt: Q8N143
Chr Location

17p13.1; chr17:7023050-7030290 (+) GRCh38

MGI Vertebrate Homology

Bcl6b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BCL6B
Gene Tree

Bcl6b

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

8
Transgenic

1
Genomic Mutations

3 involving Bcl6b
Incidental Mutations

APF
Find Mice (IMSR)

16 strains or lines available

Homozygous null mice display decreased CD4+ and CD8+ cell numbers in the thymus. Homozygous mice for one null allele display decreased secondary responses of memory CD8+ T cells.

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All GO Annotations

18
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

884
Tissues

161
cDNA Data

20
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN bcl6b

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All Sequences

39
RefSeq

4
UniProt

4
CCDS

CCDS24939.1

Ensembl

ENSMUSG00000000317 (Evidence)
NCBI Gene

12029

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000317	Ensembl Gene Model \| MGI Sequence Detail	5671	C57BL/6J	± kb
transcript	ENSMUST00000000326	Ensembl \| MGI Sequence Detail	3366	Not Applicable
polypeptide	ENSMUSP00000000326	Ensembl \| MGI Sequence Detail	474	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004701 B-cell CLL/lymphoma 6 member B protein

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR011333 SKP1/BTB/POZ domain superfamily

IPR050457 Zinc finger and BTB domain-containing

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 22

Genomic 1

cDNA 20

Primer pair 1

Microarray probesets 4

Summaries

All 55

Developmental Gene Expression 10

Gene Ontology 4

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Bcl6b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108924	Chr11:70121042-70121067 (-)	-431 bp
Tssr108923	Chr11:70120581-70120587 (-)	40 bp
Tssr108922	Chr11:70118115-70118123 (-)	2,505 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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